Oral administration of interferon tau enhances oxidation of energy substrates and reduces adiposity in Zucker diabetic fatty rats.
Oral administration of interferon tau enhances oxidation of energy substrates and reduces adiposity in Zucker diabetic fatty rats.
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DOI：
10.1002/biof.1113
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发表时间：
2013-09
期刊：
影响因子：
6
通讯作者：
Wu, Guoyao
中科院分区：
文献类型：
--
作者：
Tekwe, Carmen D.;Lei, Jian;Yao, Kang;Rezaei, Reza;Li, Xilong;Dahanayaka, Sudath;Carroll, Raymond J.;Meininger, Cynthia J.;Bazer, Fuller W.;Wu, Guoyao
以雄性Zucker糖尿病脂肪大鼠（ZDF）为研究对象，研究口服干扰素tau （IFNT）对肥胖的影响。选取18只28日龄的ZDF大鼠，随机分为每天0、4或8 μg IFNT/kg体重组（n=6/组），连续8周。每两天测量一次水的消耗量。每周记录摄食量和体重。用间接量热法测定4、6、8和10周龄大鼠的能量消耗。从7周龄开始，每天检测尿葡萄糖和酮体。8 μg IFNT/kg BW/天处理的大鼠肝脏、棕色脂肪组织和腹部脂肪组织中葡萄糖和油酸氧化率、骨骼肌中亮氨酸分解代谢率以及白色和棕色脂肪组织中的脂肪分解率均高于对照组。与对照大鼠相比，8 μg IFNT/kg BW/天治疗增加了产热，减少了体重增加和肥胖，改善了脂肪肝综合征，延缓了糖尿病的发病，降低了血浆中葡萄糖、游离脂肪酸、甘油三酯、胆固醇和支链氨基酸的浓度。口服8 μg IFNT/kg BW/天可以改善骨骼肌、肝脏和脂肪组织的氧化应激，结果表明，氧化谷胱甘肽与还原性谷胱甘肽的比例降低，抗氧化剂四氢生物terin的浓度增加。这些结果表明，IFNT刺激ZDF大鼠的能量底物氧化并减少肥胖，可能对预防和治疗哺乳动物肥胖相关疾病具有广泛的重要意义。
Male Zucker diabetic fatty (ZDF) rats were used to study effects of oral administration of interferon tau (IFNT) in reducing obesity. Eighteen ZDF rats (28 days of age) were assigned randomly to receive 0, 4 or 8 μg IFNT/kg body weight (BW) per day (n=6/group) for 8 weeks. Water consumption was measured every two days. Food intake and BW were recorded weekly. Energy expenditure in 4-, 6-, 8-, and 10-week-old rats was determined using indirect calorimetry. Starting at 7 weeks of age, urinary glucose and ketone bodies were tested daily. Rates of glucose and oleate oxidation in liver, brown adipose tissue, and abdominal adipose tissue, leucine catabolism in skeletal muscle, and lipolysis in white and brown adipose tissues were greater for rats treated with 8 μg IFNT/kg BW/day in comparison with control rats. Treatment with 8 μg IFNT/kg BW/day increased heat production, reduced BW gain and adiposity, ameliorated fatty liver syndrome, delayed the onset of diabetes, and decreased concentrations of glucose, free fatty acids, triacylglycerol, cholesterol, and branched-chain amino acids in plasma, compared to control rats. Oral administration of 8 μg IFNT/kg BW/day ameliorated oxidative stress in skeletal muscle, liver and adipose tissue, as indicated by decreased ratios of oxidized glutathione to reduced glutathione and increased concentrations of the antioxidant tetrahydrobiopterin. These results indicate that IFNT stimulates oxidation of energy substrates and reduces obesity in ZDF rats and may have broad important implications for preventing and treating obesity-related diseases in mammals.
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影响因子：
8.2
作者：
Marliss, EB;Chevalier, S;Wu, G
通讯作者：
Wu, G
影响因子：
7
作者：
Perez de Heredia, Fatima;Gomez-Martinez, Sonia;Marcos, Ascension
通讯作者：
Marcos, Ascension
影响因子：
29
作者：
Newgard CB
通讯作者：
Newgard CB
DOI：
10.1073/pnas.97.15.8536
发表时间：
2000-07-18
影响因子：
11.1
作者：
Kakuma, T;Lee, Y;Unger, RH
通讯作者：
Unger, RH
DOI：
10.2170/jjphysiol.48.211
发表时间：
1998-06-01
期刊：
JAPANESE JOURNAL OF PHYSIOLOGY
影响因子：
--
作者：
Ichikawa, M;Miyasaka, K;Funakoshi, A
通讯作者：
Funakoshi, A