Layered titanates with fibrous nanotopographic features as reservoir for bioactive ions to enhance osteogenesis
Layered titanates with fibrous nanotopographic features as reservoir for bioactive ions to enhance osteogenesis
复制标题
具有纤维纳米形貌特征的层状钛酸盐作为生物活性离子的储存库以增强成骨作用
DOI：
10.1016/j.apsusc.2017.12.027
复制
发表时间：
2018-04
影响因子：
6.7
通讯作者：
Wang Guocheng
中科院分区：
文献类型：
--
作者：
Song Xiaoxia;Tang Wei;Gregurec Danijela;Yate Luis;Moya Sergio Enrique;Wang Guocheng
在本研究中，通过原位形成纳米纤维状钛酸盐Na 2 Ti6 O 13，负载生物活性离子，即Sr，Mg和Zn，在钛合金植入物上构建成骨环境，以增强表面生物活性。生物活性离子通过与钠离子交换而负载在TiO 6片层之间的层间位置，并且它们的释放与钛酸盐结构单元的降解无关。使用MC 3 T3-E1细胞的体外细胞培养实验证明，生物活性离子和纳米形貌特征在促进细胞的成骨分化中是至关重要的。结果发现，钛酸盐的成骨功能可以通过掺入的离子的类型和量来调节。这项研究指出，钛合金上形成的纳米纤维状钛酸盐可以是一个有前途的生物活性离子库。与使用可降解生物陶瓷涂层的生物活性离子递送的其他替代方案相比，这种方法的主要优点是其保持涂层结构完整性的能力，从而避免结构劣化和潜在的机械故障。
In this study, an osteogenic environment was constructed on Ti alloy implants byin-situformation of nanosized fibrous titanate, Na2Ti6O13, loaded with bioactive ions, i.e. Sr, Mg and Zn, to enhance surface bioactivity. The bioactive ions were loaded by ion exchange with sodium located at inter-layer positions between the TiO6slabs, and their release was not associated with the degradation of the structural unit of the titanate.In-vitrocell culture experiments using MC3T3-E1 cells proved that both bioactive ions and nanotopographic features are critical in promoting osteogenic differentiation of the cells. It was found that the osteogenic functions of the titanate can be modulated by the type and amount of ions incorporated. This study points out that nanosized fibrous titanate formed on the Ti alloy can be a promising reservoir for bioactive ions. The major advantage of this approach over other alternatives for bioactive ion delivery using degradable bioceramic coatings is its capacity of maintaining the structural integrity of the coating and thus avoiding structural deterioration and potential mechanical failure.
登录
查看更多内容
DOI：
10.1083/jcb.201108062
发表时间：
2012-04-30
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kim DH;Provenzano PP;Smith CL;Levchenko A
通讯作者：
Levchenko A
影响因子：
29.4
作者：
Dong-Jiang Yang;Zhanfeng Zheng;Huaiyong Zhu;Hong Wei Liu;Xueping Gao
通讯作者：
Dong-Jiang Yang;Zhanfeng Zheng;Huaiyong Zhu;Hong Wei Liu;Xueping Gao
影响因子：
3.6
作者：
K. Mark;Jung Park;S. Bauer;P. Schmuki
通讯作者：
K. Mark;Jung Park;S. Bauer;P. Schmuki
影响因子：
6.2
作者：
A. Parfitt;L. Simon;A. Villanueva;S. Krane
通讯作者：
A. Parfitt;L. Simon;A. Villanueva;S. Krane
影响因子：
14
作者：
Lee LC;Gadegaard N;de Andrés MC;Turner LA;Burgess KV;Yarwood SJ;Wells J;Salmeron-Sanchez M;Meek D;Oreffo RO;Dalby MJ
通讯作者：
Dalby MJ