Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
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虽然lincRNA涉及各种组织中的基因调控，但对T细胞谱系中的lincRNA转录组知之甚少。在这里，我们在从早期T细胞祖细胞到终末分化的T辅助细胞（TH）亚群的42个T细胞样品中鉴定了1，524个lincRNA簇。我们的分析揭示了lincRNA在T细胞分化过程中的高度动态和细胞特异性表达模式。重要的是，这些lincRNA位于富含具有免疫调节功能的蛋白质编码基因的基因组区域。它们中的许多被关键T细胞转录因子T-bet、加塔-3、STAT 4和STAT 6结合和调节。我们证明lincRNA LincR-Ccr 2 -5′AS与加塔-3一起是TH 2特异性基因表达调控回路的重要组成部分，对TH 2细胞迁移非常重要。
Although lincRNAs are implicated in gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identify 1,524 lincRNA clusters in 42 T cell samples from early T cell progenitors to terminally differentiated T helper (TH) subsets. Our analysis revealed highly dynamic and cell-specific expression patterns of lincRNAs during T cell differentiation. Importantly, these lincRNAs are located in genomic regions enriched for protein-coding genes with immune-regulatory functions. Many of them are bound and regulated by the key T cell transcription factors T-bet, GATA-3, STAT4 and STAT6. We demonstrate that the lincRNA LincR-Ccr2-5′AS, together with GATA-3, is an essential component of a regulatory circuit in TH2-specific gene expression and important for TH2 cell migration.
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影响因子：
64.5
作者：
Huarte M;Guttman M;Feldser D;Garber M;Koziol MJ;Kenzelmann-Broz D;Khalil AM;Zuk O;Amit I;Rabani M;Attardi LD;Regev A;Lander ES;Jacks T;Rinn JL
通讯作者：
Rinn JL
影响因子：
64.5
作者：
Gomez JA;Wapinski OL;Yang YW;Bureau JF;Gopinath S;Monack DM;Chang HY;Brahic M;Kirkegaard K
通讯作者：
Kirkegaard K
影响因子：
32.4
作者：
Nakayamada S;Kanno Y;Takahashi H;Jankovic D;Lu KT;Johnson TA;Sun HW;Vahedi G;Hakim O;Handon R;Schwartzberg PL;Hager GL;O'Shea JJ
通讯作者：
O'Shea JJ
影响因子：
14.9
作者：
Flicek P;Ahmed I;Amode MR;Barrell D;Beal K;Brent S;Carvalho-Silva D;Clapham P;Coates G;Fairley S;Fitzgerald S;Gil L;García-Girón C;Gordon L;Hourlier T;Hunt S;Juettemann T;Kähäri AK;Keenan S;Komorowska M;Kulesha E;Longden I;Maurel T;McLaren WM;Muffato M;Nag R;Overduin B;Pignatelli M;Pritchard B;Pritchard E;Riat HS;Ritchie GR;Ruffier M;Schuster M;Sheppard D;Sobral D;Taylor K;Thormann A;Trevanion S;White S;Wilder SP;Aken BL;Birney E;Cunningham F;Dunham I;Harrow J;Herrero J;Hubbard TJ;Johnson N;Kinsella R;Parker A;Spudich G;Yates A;Zadissa A;Searle SM
通讯作者：
Searle SM
影响因子：
4.4
作者：
Mathew, A;Medoff, BD;Luster, AD
通讯作者：
Luster, AD