Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review.

Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review.
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DOI:
10.3389/fnins.2021.649910
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发表时间:
2021
影响因子:
4.3
通讯作者:
Li C
Li C
中科院分区:
医学2区
文献类型:
--
作者:
White TG;Powell K;Shah KA;Woo HH;Narayan RK;Li C

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已知三叉神经,即第五脑神经,支配大部分脑动脉血管系统,并且在健康和患病状态下显著有助于控制脑血管紧张度。以往的研究表明,刺激三叉神经(TNS)增加脑血流量(CBF)通过逆行,三叉神经副交感神经,和其他中枢途径。尽管之前有一些关于三叉神经的作用及其对CBF的控制的报道,但只有少数研究调查了TNS对脑灌注障碍的影响(即,缺血性中风、蛛网膜下腔出血和创伤性脑损伤)。在这篇微型综述中,我们介绍了目前关于三叉神经控制CBF的机制、靶向治疗的解剖学基础以及TNS的潜在临床应用的知识,重点关注脑灌注受损的治疗。
The trigeminal nerve, the fifth cranial nerve, is known to innervate much of the cerebral arterial vasculature and significantly contributes to the control of cerebrovascular tone in both healthy and diseased states. Previous studies have demonstrated that stimulation of the trigeminal nerve (TNS) increases cerebral blood flow (CBF) via antidromic, trigemino-parasympathetic, and other central pathways. Despite some previous reports on the role of the trigeminal nerve and its control of CBF, there are only a few studies that investigate the effects of TNS on disorders of cerebral perfusion (i.e., ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury). In this mini review, we present the current knowledge regarding the mechanisms of trigeminal nerve control of CBF, the anatomic underpinnings for targeted treatment, and potential clinical applications of TNS, with a focus on the treatment of impaired cerebral perfusion.
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