Suppression of endogenous murine leukemia virus by maternal resistance factor.
Suppression of endogenous murine leukemia virus by maternal resistance factor.
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DOI：
10.1084/jem.158.2.506
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发表时间：
1983-08-01
期刊：
影响因子：
--
通讯作者：
Duran-Reynals ML
中科院分区：
文献类型：
--
作者：
Melamedoff M;Lilly F;Duran-Reynals ML
Females of the RF and SJL inbred mouse strains transmit to their progeny of both sexes a nonmendelian maternal resistance factor (MRF) able to suppress the expression of endogenous ecotropic murine leukemia virus (E-MuLV). This MRF is demonstrable in crosses with AKR mice by comparing E-MuLV expression in the spleens and thymuses of reciprocal F1 generations. DBA/2 and ST/b mice are MRF negative by these criteria. Neonatal inoculation of E-MuLV-containing spleen extracts gives rise to persistent expression of infectious virus in mice of the MRF- but not the MRF+ strains. However, inoculation of the virus in 30-d-old females of the MRF- strains no longer leads to a state of persistent infection; instead, these females become MRF+ and transmit protection against E- MuLV expression to their progeny by AKR and RF males. The MRF appears to be transmitted to the progeny mainly through the milk, since foster- nursing AKR neonates on RF (but not DBA/2) mothers greatly reduces E- MuLV expression in the progeny. These RF-fostered AKR mice also show a reduced and delayed lymphoma incidence, a finding consistent with the idea that maternally transmitted resistance to E-MuLV expression is the basis for the classic maternal resistance to lymphomagenesis seen in the progeny of RF mothers.
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影响因子：
64.5
作者：
MAYER, A;STRUUCK, FD;LILLY, F
通讯作者：
LILLY, F
影响因子：
64.5
作者：
CHEN, S;STRUUCK, FD;LILLY, F
通讯作者：
LILLY, F
影响因子：
15.3
作者：
MCCUBREY, J;HOROWITZ, JM;RISSER, R
通讯作者：
RISSER, R
影响因子：
5.4
作者：
JENKINS, NA;COPELAND, NG;LEE, BK
通讯作者：
LEE, BK
影响因子：
3.7
作者：
SCHWARZ, H;IHLE, JN;SCHAFER, W
通讯作者：
SCHAFER, W