Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells.
Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells.
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DOI：
10.1186/1742-4933-10-28
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发表时间：
2013-07-11
期刊：
影响因子：
--
通讯作者：
Scapagnini G
中科院分区：
文献类型：
--
作者：
Davinelli S;Sapere N;Visentin M;Zella D;Scapagnini G
新出现的证据表明，许多生物活性化合物的组合作用可能是各种治疗应用中的有价值的来源。几种营养保健品已被证明可以增强药理学方法的功效或提供生理益处以改善与年龄相关的衰退。最近，抗衰老干预措施的可能性也成倍增加，以改善衰老相关疾病中的线粒体改变。在这份报告中，我们探讨了一种新的治疗策略，结合两种生物活性的饮食成分（白藜芦醇和雌马酚），以确定其对线粒体功能的影响。考虑到白藜芦醇和雌马酚的生物活性已经在广泛的生物过程中观察到，选择它们来检查将它们组合是否会更有效地调节线粒体功能。在HUVEC细胞中，我们的结果表明，这些天然产物的共同施用增加了线粒体质量和线粒体DNA含量。此外，两种化合物的联合使用增加了SIRT 1酶活性，并诱导了线粒体生物合成因子，如PGC 1-α、TFAM和NRF-1。因此，这种新的协同作用的鉴定可能为未来的治疗提供新的视角，旨在调节线粒体活性，并影响维持内皮功能，这在免疫应答的调节中至关重要。进一步的研究发现这种串扰的分子细节，并确定影响线粒体功能的活性化合物的新组合，将是非常有益的，以防止线粒体下降。
Emerging evidence suggests that combinatorial action of numerous biologically active compounds may be a valuable source in a variety of therapeutic applications. Several nutraceuticals have demonstrated to augment the efficacy of pharmacological approaches or provide physiological benefit to improve age-related decline. Recently, the possibilities of anti-ageing interventions have multiplied also to ameliorate the mitochondrial alterations in ageing-associated diseases. In this report, we approached a novel treatment strategy by combining two bioactive dietary constituents (resveratrol and equol) to determine their effect on mitochondrial function. Taking into account that the biological activities of resveratrol and equol has been observed in a wide range of biological processes, they were selected to examine whether combining them would be more effective to modulate mitochondrial function. In HUVEC cells our results demonstrate that the co-administration of these natural products increased mitochondrial mass and mitochondrial DNA content. Additionally, combined use of both compounds increased SIRT1 enzymatic activity and induced mitochondrial biogenesis factors such as PGC1-α, TFAM and NRF-1. Therefore, identification of this novel synergism may provide a new perspective for future treatments aiming to modulate the mitochondrial activity with implications in maintaining endothelial function which is crucial in the regulation of immune response. Further studies to discover the molecular details of this crosstalk and to identify new combinations of active compounds affecting the mitochondrial function will be extremely beneficial to prevent mitochondrial decline.
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影响因子：
3.1
作者：
Davinelli, Sergio;Di Marco, Roberto;Scapagnini, Giovanni
通讯作者：
Scapagnini, Giovanni
影响因子：
3.9
作者：
Grillari, J;Hohenwarter, O;Katinger, H
通讯作者：
Katinger, H
影响因子：
6.1
作者：
Rüfer, CE;Kulling, SE
通讯作者：
Kulling, SE
影响因子：
11.4
作者：
Biswas, G;Adebanjo, OA;Avadhani, NG
通讯作者：
Avadhani, NG
影响因子：
5.3
作者：
Jendrach, M;Pohl, S;Bereiter-Hahn, J
通讯作者：
Bereiter-Hahn, J