A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity.
A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity.
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DOI：
10.1186/s12987-020-00230-3
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发表时间：
2020-11-18
影响因子：
7.3
通讯作者：
Cucullo L
中科院分区：
文献类型：
--
作者：
Kadry H;Noorani B;Cucullo L
血脑屏障在控制脑代谢活动和神经功能所必需的生物物质的流入和流出方面起着关键作用。因此，BBB的功能和结构完整性对于维持脑微环境的稳态是关键的。沿着总结了促进血脑屏障形成的不同细胞和结构，以及血脑屏障在脑-血界面发挥的不同功能。我们还解释了剪切应力在维持血脑屏障完整性中的作用。此外，我们详细阐述了BBB破坏与不同神经和病理状况之间相关的临床方面。最后，我们讨论了几种生物标志物，可以帮助评估血脑屏障的通透性和完整性在体外或体内，并简要说明其优点和缺点。
The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activity as well as neuronal function. Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment. The different cells and structures contributing to developing this barrier are summarized along with the different functions that BBB plays at the brain–blood interface. We also explained the role of shear stress in maintaining BBB integrity. Furthermore, we elaborated on the clinical aspects that correlate between BBB disruption and different neurological and pathological conditions. Finally, we discussed several biomarkers that can help to assess the BBB permeability and integrity in-vitro or in-vivo and briefly explain their advantages and disadvantages.
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影响因子：
8
作者：
Berndt, Philipp;Winkler, Lars;Haseloff, Reiner F.
通讯作者：
Haseloff, Reiner F.
影响因子：
64.8
作者：
Ben-Zvi, Ayal;Lacoste, Baptiste;Kur, Esther;Andreone, Benjamin J.;Mayshar, Yoav;Yan, Han;Gu, Chenghua
通讯作者：
Gu, Chenghua
影响因子：
3.9
作者：
Alqahtani, Faleh;Chowdhury, Ekram Ahmed;Bickel, Ulrich
通讯作者：
Bickel, Ulrich
DOI：
10.1073/pnas.95.10.5795
发表时间：
1998-05-12
影响因子：
11.1
作者：
Akama, KT;Albanese, C;Van Eldik, LJ
通讯作者：
Van Eldik, LJ
影响因子：
4.2
作者：
Abbott, NJ
通讯作者：
Abbott, NJ