A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.
A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.
复制标题
DOI：
10.1016/j.wneu.2016.04.026
复制
发表时间：
2016-07
影响因子：
2
通讯作者：
Sciubba DM
中科院分区：
文献类型：
--
作者：
Goodwin CR;Yanamadala V;Ruiz-Valls A;Abu-Bonsrah N;Shankar G;Sankey EW;Boone C;Clarke MJ;Bilsky M;Laufer I;Fisher C;Shin JH;Sciubba DM
背景肝细胞癌（HCC）经常转移至脊柱。医学和/或手术干预对总体生存率的影响已在有限数量的临床研究中进行了检验，在此我们系统地回顾了这些数据。方法我们使用 PubMed、Embase、CINAHL 和 Web of Science 进行了文献综述，以识别报告与诊断为脊柱转移瘤的患者相关的生存率、临床结果和/或预后因素的文章。使用系统评价和荟萃分析工具的首选报告项目评估每项评价的方法学质量。结果有 26 篇文章（152 名患者）符合纳入标准，并接受了手术、放疗、化疗和/或观察治疗。共有 3 项回顾性队列研究、17 份病例报告、5 项病例系列研究和 1 项纵向观察研究。诊断脊柱转移后已知总生存率的患者中，3个月、6个月、1年、2年和5年生存率分别为95.2%、83.0%、28.6%、2.0%和1.4%。诊断出转移后，未接受任何治疗的患者的中位生存期为 0.7 个月，仅接受手术治疗的患者为 7 个月，接受化疗和/或放疗的患者为 6 个月，而接受手术和药物治疗相结合的患者为 13.5 个月。所有其他临床或预后参数均较低或强度不足。结论诊断为 HCC 脊柱转移的患者的总生存期为 10.6 个月。在前瞻性对照试验中对患者进行进一步分析对于未来为这些患者开发治疗算法至关重要。
BackgroundHepatocellular carcinoma (HCC) frequently metastasizes to the spine. The impact of medical and/or surgical intervention on overall survival has been examined in a limited number of clinical studies, and herein we systematically review these data.MethodsWe performed a literature review using PubMed, Embase, CINAHL, and Web of Science to identify articles that reported survival, clinical outcomes, and/or prognostic factors associated with patients diagnosed with spinal metastases. The methodologic quality of each review was assessed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses tool.ResultsThere were 26 articles (152 patients) that met the inclusion criteria and were treated with either surgery, radiotherapy, chemotherapy, and/or observation. There were 3 retrospective cohort studies, 17 case reports, 5 case series, and 1 longitudinal observational study. Of the patients with known overall survival after diagnosis of spinal metastasis, survival at 3 months, 6 months, 1 year, 2 years, and 5 years was 95.2%, 83.0%, 28.6%, 2.0%, and 1.4%, respectively. The median survival after diagnosis of the metastasis was 0.7 months in the patients who received no treatment, 7 months in the patients treated with surgical intervention alone, 6 months for patients who received chemotherapy and/or radiation, and 13.5 months in the patients treated with a combination of surgery and medical management. All other clinical or prognostic parameters were of low or insufficient strength.ConclusionsPatients diagnosed with HCC spinal metastasis have a 10.6-month overall survival. Further analysis of patients in prospective controlled trials will be essential to the development of treatment algorithms for these patients in the future.
登录
查看更多内容
DOI：
10.1007/s00432-008-0410-6
发表时间：
2008-12-01
影响因子：
3.6
作者：
Kim, Seung Up;Kim, Do Young;Han, Kwang-Hyub
通讯作者：
Han, Kwang-Hyub
DOI：
10.1016/s0360-3016(99)00333-8
发表时间：
2000-03-15
影响因子：
7
作者：
Helweg-Larsen, S;Sorensen, PS;Kreiner, S
通讯作者：
Kreiner, S
影响因子：
8.9
作者：
Kim HJ;Lee HW
通讯作者：
Lee HW
影响因子：
0.9
作者：
Abbas, Syed Hussain;Khan, Muhammad Zia Ul Islam;Hussain, Syed Jawad Akhtar
通讯作者：
Hussain, Syed Jawad Akhtar
影响因子：
4.8
作者：
Chaichana, Kaisorn L.;Woodworth, Graeme F.;Gokaslan, Ziya
通讯作者：
Gokaslan, Ziya