Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.
复制标题
DOI：
10.1016/j.cmet.2010.03.002
复制
发表时间：
2010-04-07
期刊：
影响因子：
29
通讯作者：
Elmquist JK
中科院分区：
文献类型：
--
作者：
Hill JW;Elias CF;Fukuda M;Williams KW;Berglund ED;Holland WL;Cho YR;Chuang JC;Xu Y;Choi M;Lauzon D;Lee CE;Coppari R;Richardson JA;Zigman JM;Chua S;Scherer PE;Lowell BB;Brüning JC;Elmquist JK
循环中的瘦素和胰岛素将能量储存的信息传递给中枢神经系统，特别是下丘脑。下丘脑前阿黑皮素（POMC）神经元调节能量平衡和葡萄糖稳态，并表达瘦素和胰岛素受体。然而，伴随的瘦素和胰岛素对POMC神经元的作用的生理意义仍有待建立。在这里，我们表明，缺乏胰岛素和LepRs的小鼠POMC神经元（Pomc-Cre，Leprflox/flox IRflox/flox小鼠）显示全身性胰岛素抵抗，这是不同的单一缺失的受体。此外，Pomc-Cre、Leprflox/flox、IRflox/flox雌性小鼠显示血清睾酮水平升高和卵巢异常，导致生育力降低。我们的结论是胰岛素和瘦素对POMC神经元的直接作用是维持正常的葡萄糖稳态和生殖功能所必需的。
Circulating leptin and insulin convey information regarding energy stores to the central nervous system, particularly the hypothalamus. Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy balance and glucose homeostasis and express leptin and insulin receptors. However, the physiological significance of concomitant leptin and insulin action on POMC neurons remains to be established. Here we show that mice lacking both insulin and LepRs in POMC neurons (Pomc-Cre, Leprflox/flox IRflox/flox mice) display systemic insulin resistance, which is distinct from the single deletion of either receptor. In addition, Pomc-Cre, Leprflox/flox IRflox/flox female mice display elevated serum testosterone levels and ovarian abnormalities resulting in reduced fertility. We conclude that direct action of insulin and leptin on POMC neurons is required to maintain normal glucose homeostasis and reproductive function.
登录
查看更多内容
影响因子：
16.2
作者：
Dhillon, H;Zigman, JM;Lowelll, BB
通讯作者：
Lowelll, BB
影响因子：
29
作者：
Al-Qassab H;Smith MA;Irvine EE;Guillermet-Guibert J;Claret M;Choudhury AI;Selman C;Piipari K;Clements M;Lingard S;Chandarana K;Bell JD;Barsh GS;Smith AJ;Batterham RL;Ashford ML;Vanhaesebroeck B;Withers DJ
通讯作者：
Withers DJ
影响因子：
16.2
作者：
Elias, CF;Aschkenasi, C;Elmquist, JK
通讯作者：
Elmquist, JK
DOI：
10.1038/oby.2005.7
发表时间：
2005-01-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Carvalheira, JBC;Torsoni, MA;Saad, MJA
通讯作者：
Saad, MJA
影响因子：
4.8
作者：
ADASHI, EY;HSUEH, AJW;YEN, SSC
通讯作者：
YEN, SSC