Orally administered δ opioid agonist peptide rubiscolin-6 stimulates food intake in aged mice with ghrelin resistance.
Orally administered δ opioid agonist peptide rubiscolin-6 stimulates food intake in aged mice with ghrelin resistance.
复制标题
口服 δ 阿片受体激动剂肽 rubiscolin-6 可刺激具有生长素释放肽抗性的老年小鼠的食物摄入。
DOI：
10.1002/mnfr.201400100
复制
发表时间：
2014
影响因子：
5.2
通讯作者：
Ohinata K.
中科院分区：
文献类型：
--
作者：
Miyazaki Y;Kaneko K;Iguchi S;Mizushige T;Kanamoto R;Yoshikawa M;Shimizu T;Ohinata K.
范围众所周知，随着年龄的增长，食物摄入量会下降。在这项研究中，我们调查了与食物摄入量相关的参数的变化，以应对衰老，以及食欲肽是否刺激食物摄入后，外周给药，即使在老年mice.Methods和resultsFood intake和体重的27个月大的雄性C57 BL/6 N小鼠低于15个月大的小鼠。附睾和肠系膜脂肪量、血糖、甘油三酯和瘦素水平也降低。同时，下丘脑内源性食欲肽如神经肽Y（NPY）和agglutin-related蛋白（也称为agglutin-related peptide）的mRNA表达增加。接下来，我们测试了老年小鼠和年轻小鼠对外源性给予的与NPY偶联的食欲肽的反应性。口服rubiscolin-6（一种源自主要绿色叶蛋白Rubisco的δ阿片类激动剂六肽）刺激27月龄小鼠的摄食。相反，老年小鼠腹腔注射ghrelin无效，提示老年小鼠ghrelin下游的NPY系统受损，而δ阿片受体未受损。ConclusionOrally administered rubiscolin-6刺激ghrelin抵抗的老年小鼠摄食。
ScopeIt is known that a decline in food intake occurs with aging. In this study, we investigated changes in parameters associated with food intake in response to aging, and whether orexigenic peptides stimulated food intake after peripheral administration even in aged mice.Methods and resultsFood intake and body weight of 27‐month‐old male C57BL/6N mice were lower than those of 15‐month‐old mice. Epididymal and mesenteric fat mass, blood glucose, triglyceride, and leptin levels were also decreased. Meanwhile, the hypothalamic mRNA expression of endogenous orexigenic peptides such as neuropeptide Y (NPY) and agouti‐related protein, also called agouti‐related peptide, was increased. Next, we tested responsiveness to exogenously administered orexigenic peptides coupled to NPY in aged as well as young mice. Orally administered rubiscolin‐6, a δ opioid agonist hexapeptide derived from a major green leaf protein Rubisco, stimulated food intake in 27‐month‐old mice. In contrast, ghrelin was ineffective after intraperitoneal administration to aged mice, suggesting that the NPY system downstream of ghrelin but not δ opioid receptors might be impaired in aged mice.ConclusionOrally administered rubiscolin‐6 stimulates food intake in aged mice with ghrelin resistance.
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