Mayaro Virus Pathogenesis and Transmission Mechanisms.
Mayaro Virus Pathogenesis and Transmission Mechanisms.
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DOI：
10.3390/pathogens9090738
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发表时间：
2020-09-08
期刊：
影响因子：
--
通讯作者：
Missé D
中科院分区：
文献类型：
--
作者：
Diagne CT;Bengue M;Choumet V;Hamel R;Pompon J;Missé D
马亚罗病毒（MAYV）首次在特立尼达和托巴哥分离，在最近美洲爆发后引起了全世界公共卫生当局的注意。由于其病媒分布广泛，该病毒倾向于出口到其原有地理范围之外。此外，世界上大多数人口对MAYV感染的免疫学幼稚，这使得这种病毒成为真正的威胁。白纹伊蚊最近入侵几个国家，突出表明了热带和温带地区的MAYV潜在城市传播风险。在人类中，MAYV疾病的临床表现范围从轻度发热、皮疹和关节痛到关节痛。在没有许可的疫苗和临床证明的马亚罗热疗法的情况下，预防工作主要集中在家庭蚊虫控制上。然而，正如其他虫媒病毒所证明的那样，蚊子控制对于暴发管理是相当低效的，因此有必要采取替代方法来遏制MAYV的传播。尽管它具有很强的流行潜力，但目前对MAYV知之甚少。本文综述了MAYV的各个方面，包括其流行病学、媒介生物学、传播方式和临床并发症，以及MAYV诊断的最新进展。
Mayaro virus (MAYV), isolated for the first time in Trinidad and Tobago, has captured the attention of public health authorities worldwide following recent outbreaks in the Americas. It has a propensity to be exported outside its original geographical range, because of the vast distribution of its vectors. Moreover, most of the world population is immunologically naïve with respect to infection with MAYV which makes this virus a true threat. The recent invasion of several countries by Aedes albopictus underscores the risk of potential urban transmission of MAYV in both tropical and temperate regions. In humans, the clinical manifestations of MAYV disease range from mild fever, rash, and joint pain to arthralgia. In the absence of a licensed vaccine and clinically proven therapeutics against Mayaro fever, prevention focuses mainly on household mosquito control. However, as demonstrated for other arboviruses, mosquito control is rather inefficient for outbreak management and alternative approaches to contain the spread of MAYV are therefore necessary. Despite its strong epidemic potential, little is currently known about MAYV. This review addresses various aspects of MAYV, including its epidemiology, vector biology, mode of transmission, and clinical complications, as well as the latest developments in MAYV diagnosis.
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DOI：
10.1093/infdis/jiq042
发表时间：
2011-01-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Chow A;Her Z;Ong EK;Chen JM;Dimatatac F;Kwek DJ;Barkham T;Yang H;Rénia L;Leo YS;Ng LF
通讯作者：
Ng LF
影响因子：
2.7
作者：
Carvalho CAM;Silva JL;Oliveira AC;Gomes AMO
通讯作者：
Gomes AMO
影响因子：
3.8
作者：
Brustolin M;Pujhari S;Henderson CA;Rasgon JL
通讯作者：
Rasgon JL
影响因子：
11.8
作者：
Azevedo, Raimunda S. S.;Silva, Eliana V. P.;Vasconcelos, Pedro F. C.
通讯作者：
Vasconcelos, Pedro F. C.
影响因子：
3.8
作者：
Achee NL;Gould F;Perkins TA;Reiner RC Jr;Morrison AC;Ritchie SA;Gubler DJ;Teyssou R;Scott TW
通讯作者：
Scott TW