Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor.
Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor.
复制标题
DOI：
10.1093/infdis/jiq042
复制
发表时间：
2011-01-15
期刊：
影响因子：
--
通讯作者：
Ng LF
中科院分区：
文献类型：
--
作者：
Chow A;Her Z;Ong EK;Chen JM;Dimatatac F;Kwek DJ;Barkham T;Yang H;Rénia L;Leo YS;Ng LF
背景资料。基孔肯雅病毒(CHIKV)感染会导致关节疼痛。炎症细胞因子和趋化因子参与了CHIKV感染，但对其在CHIKV感染患者中的分泌情况知之甚少。方法：研究方法。进行了一项病例对照纵向研究，涉及30名经实验室确认的基孔肯雅热成人患者。对他们的临床疾病、病毒载量和免疫介质进行了调查。结果。当患者在急性期被分成高病毒载量组和低病毒载量组时，高病毒血症组有淋巴细胞减少、单核细胞水平降低、中性粒细胞减少和炎症迹象。高病毒载量组的特征还包括在急性期产生更高的促炎细胞因子，如干扰素-α和白介素6。随着疾病发展到慢性期，IL-17变得可检测到。然而，持续性关节痛与较高水平的IL-6和粒细胞巨噬细胞集落刺激因子有关，而完全康复的患者则有较高水平的嗜酸性粒细胞趋化因子和肝细胞生长因子。结论。急性期CHIKV病毒血症的水平决定了促炎细胞因子的特定模式，这些细胞因子与疾病的严重程度相关。在慢性期，IL-6和粒细胞巨噬细胞集落刺激因子的水平被发现与持续性关节痛有关，为困扰许多CHIKV感染患者的关节痛的病因提供了可能的解释。
Background. Chikungunya virus (CHIKV) infection induces arthralgia. The involvement of inflammatory cytokines and chemokines has been suggested, but very little is known about their secretion profile in CHIKV-infected patients. Methods. A case-control longitudinal study was performed that involved 30 adult patients with laboratory-confirmed Chikungunya fever. Their profiles of clinical disease, viral load, and immune mediators were investigated. Results. When patients were segregated into high viral load and low viral load groups during the acute phase, those with high viremia had lymphopenia, lower levels of monocytes, neutrophilia, and signs of inflammation. The high viral load group was also characterized by a higher production of pro-inflammatory cytokines, such as interferon-α and interleukin (IL)–6, during the acute phase. As the disease progressed to the chronic phase, IL-17 became detectable. However, persistent arthralgia was associated with higher levels of IL-6 and granulocyte macrophage colony-stimulating factor, whereas patients who recovered fully had high levels of Eotaxin and hepatocyte growth factor. Conclusions. The level of CHIKV viremia during the acute phase determined specific patterns of pro-inflammatory cytokines, which were associated with disease severity. At the chronic phase, levels of IL-6, and granulocyte macrophage colony-stimulating factor found to be associated with persistent arthralgia provide a possible explanation for the etiology of arthralgia that plagues numerous CHIKV-infected patients.
登录
查看更多内容
DOI：
10.1196/annals.1297.021
发表时间：
2004-01-01
期刊：
STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE
影响因子：
--
作者：
Aspinall, R;Henson, S;Ngom, PT
通讯作者：
Ngom, PT
影响因子：
11.8
作者：
AbuBakar, Sazaly;Sam, I-Ching;Roslan, Nuruliza
通讯作者：
Roslan, Nuruliza
影响因子：
4.4
作者：
Hoarau, Jean-Jacques;Bandjee, Marie-Christine Jaffar;Gasque, Philippe
通讯作者：
Gasque, Philippe
DOI：
10.1161/01.atv.0000163840.63685.0c
发表时间：
2005-06-01
影响因子：
8.7
作者：
Arnaud, C;Burger, F;Mach, F
通讯作者：
Mach, F
DOI：
10.1073/pnas.91.9.3652
发表时间：
1994-04-26
影响因子：
11.1
作者：
CARR, MW;ROTH, SJ;SPRINGER, TA
通讯作者：
SPRINGER, TA