Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy.
Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy.
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纳米颗粒与树突状细胞之间的相互作用：从癌症免疫治疗的角度
DOI：
10.3389/fonc.2018.00404
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发表时间：
2018
影响因子：
4.7
通讯作者：
Zhai S
中科院分区：
文献类型：
--
作者：
Jia J;Zhang Y;Xin Y;Jiang C;Yan B;Zhai S
树突状细胞（Dendritic cells，DCs）是主要的抗原提呈细胞，在先天性和适应性免疫系统的协调中起关键作用。通过纳米技术靶向DC是癌症免疫治疗的一种有前途的策略。纳米颗粒的物理化学性质影响其与DC的相互作用，从而通过改变其在成熟、归巢、抗原加工和抗原呈递过程中的功能来改变DC的免疫结果。本文综述了近年来NPs作为肿瘤免疫治疗药物载体靶向DCs的研究进展、DCs对NPs的识别以及NPs的理化性质对DCs功能的影响。最后，还讨论了NPs影响DC的分子途径。
Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles in the orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology stands as a promising strategy for cancer immunotherapy. The physicochemical properties of nanoparticles (NPs) influence their interactions with DCs, thus altering the immune outcome of DCs by changing their functions in the processes of maturation, homing, antigen processing and antigen presentation. In this review, we summarize the recent progress in targeting DCs using NPs as a drug delivery carrier in cancer immunotherapy, the recognition of NPs by DCs, and the ways the physicochemical properties of NPs affect DCs' functions. Finally, the molecular pathways in DCs that are affected by NPs are also discussed.
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DOI：
10.1016/j.nano.2014.11.004
发表时间：
2015-04-01
影响因子：
5.4
作者：
Fytianos, Kleanthis;Rodriguez-Lorenzo, Laura;Rothen-Rutishauser, Barbara
通讯作者：
Rothen-Rutishauser, Barbara
影响因子：
10.8
作者：
Batista de Faria, Paula Cristina;dos Santos, Luara Isabela;Gazzinelli, Ricardo Tostes
通讯作者：
Gazzinelli, Ricardo Tostes
影响因子：
29.7
作者：
Blum JS;Wearsch PA;Cresswell P
通讯作者：
Cresswell P
氢氧化铝纳米颗粒的聚乙烯亚胺修饰增强树突状细胞的抗原运输和交叉呈递
影响因子：
8
作者：
Dong H;Wen ZF;Chen L;Zhou N;Liu H;Dong S;Hu HM;Mou Y
通讯作者：
Mou Y
影响因子：
10.8
作者：
Cruz, Luis J.;Tacken, Paul J.;Figdor, Carl G.
通讯作者：
Figdor, Carl G.