Epidemiology and natural history of intestinal metaplasia of the gastroesophageal junction and Barrett's esophagus: a population-based study.
Epidemiology and natural history of intestinal metaplasia of the gastroesophageal junction and Barrett's esophagus: a population-based study.
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DOI：
10.1038/ajg.2011.130
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发表时间：
2011-08
影响因子：
9.8
通讯作者：
Prasad, Ganapathy A.
中科院分区：
文献类型：
--
作者：
Jung, Kee Wook;Talley, Nicholas J.;Romero, Yvonne;Katzka, David A.;Schleck, Cathy D.;Zinsmeister, Alan R.;Dunagan, Kelly T.;Lutzke, Lori S.;Wu, Tsung-Teh;Wang, Kenneth K.;Frederickson, Mary;Geno, Debra M.;Locke, G. Richard;Prasad, Ganapathy A.
关于胃食管连接部肠上皮化生（IMGEJ）和Barrett食管（BE）受试者的流行病学和结局的基于人群的数据有限。本研究的目的是（i）估计明尼苏达州奥姆斯特德县30年（1976-2006）内通过临床内镜检查诊断的IMGEJ和BE的发生率以及截至2007年1月1日的患病率，（ii）比较IMGEJ和BE受试者的基线特征，（iii）研究两个队列的自然史和生存率。这是一项基于人群的队列研究。研究地点是明尼苏达州奥姆斯特德县。使用罗切斯特流行病学项目资源，对1976年至2006年明尼苏达州奥姆斯特德县BE（柱状段> 1 cm伴肠化生）和IMGEJ（胃食管连接处活检中的肠化生）患者进行鉴定。人口统计学和临床数据从病历和胃肠道病理学家证实的病理学中提取。使用比例风险回归模型评估基线特征与总体和无进展生存期的相关性。结果指标为IMGEJ受试者与BE受试者相比的基线特征和总生存期。总共确定了487例患者（401例BE患者和86例IMGEJ患者），并随访了中位间隔7年（BE受试者）至8年（IMGEJ受试者）。BE受试者年龄较大，体重较重，更常报告反流症状，晚期肿瘤的患病率高于IMGEJ受试者。与BE受试者相比，IMGEJ患者无进展为食管腺癌（EAC），BE受试者10年时的累积进展风险为7%，EAC死亡风险增加（标准化死亡率比9.62）。BE和IMGEJ受试者的总生存期与相似年龄和性别分布的明尼苏达州白色人群的预期生存期没有差异。与BE患者相比，IMGEJ受试者似乎具有独特的临床特征和显著降低的癌症进展风险。
Population-based data on the epidemiology and outcomes of subjects with intestinal metaplasia of the gastroesophageal junction (IMGEJ) and Barrett's esophagus (BE) are limited. The objectives of this study were to (i) estimate the incidence of IMGEJ and BE diagnosed from clinically indicated endoscopy in Olmsted County, MN, over three decades (1976–2006) and prevalence as of 1 January 2007, (ii) compare baseline characteristics of subjects with IMGEJ and BE, and (iii) study the natural history and survival of both cohorts. This was a population-based cohort study. The study setting was Olmsted County, MN. Patients with BE (columnar segment > 1 cm with intestinal metaplasia) and IMGEJ (intestinal metaplasia in biopsies from the gastroesophageal junction) from 1976 to 2006 in Olmsted County, MN, were identified using Rochester Epidemiology Project resources. Demographic and clinical data were abstracted from medical records and pathology confirmed by gastrointestinal pathologists. The association of baseline characteristics with overall and progression-free survival was assessed using proportional hazards regression models. Outcome measures were baseline characteristics and overall survival of subjects with IMGEJ compared to those with BE. In all, 487 patients (401 with BE and 86 with IMGEJ) were identified and followed for a median interval of 7 (BE subjects) to 8 (IMGEJ subjects) years. Subjects with BE were older, heavier, reported reflux symptoms more often, and had higher prevalence of advanced neoplasia than those with IMGEJ. No patient with IMGEJ progressed to esophageal adenocarcinoma (EAC) in contrast to BE subjects who had a cumulative risk of progression of 7% at 10 years and increased risk of death from EAC (standardized mortality ratio 9.62). The overall survival of subjects with BE and IMGEJ did not differ from that expected in similar age- and sex-distributed white Minnesota populations. Subjects with IMGEJ appear to have distinct clinical characteristics and substantially lower cancer progression risk compared to those with BE.
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影响因子：
29.4
作者：
Spechler, SJ
通讯作者：
Spechler, SJ
DOI：
10.1097/00042737-199911000-00014
发表时间：
1999-11-01
影响因子：
2.1
作者：
Peck-Radosavljevica, M;Püspök, A;Oberhuber, G
通讯作者：
Oberhuber, G
影响因子：
3.1
作者：
Nurgalieva, Zhannat;Lowrey, Angus;El-Serag, Hashem B.
通讯作者：
El-Serag, Hashem B.
影响因子：
5.6
作者：
Chandrasoma, Parakrama;Wickramasinghe, Kumari;DeMeester, Tom
通讯作者：
DeMeester, Tom
影响因子：
29.4
作者：
CAMERON, AJ;LOMBOY, CT
通讯作者：
LOMBOY, CT