Mini-review: Microtubule sliding in neurons.

Mini-review: Microtubule sliding in neurons.
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DOI:
10.1016/j.neulet.2021.135867
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发表时间:
2021-05-14
影响因子:
2.5
通讯作者:
Baas PW
Baas PW
中科院分区:
医学4区
文献类型:
--
作者:
Guha S;Patil A;Muralidharan H;Baas PW

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微管滑动是一种未被充分认识的机制,它有助于神经元微管阵列的建立、组织、保存和可塑性。由分子马达蛋白提供动力并部分由静态交联剂蛋白调节,微管滑动是微管相对于其他微管或非微管结构(如肌动蛋白细胞骨架)的运动。除了其他重要的功能,微管滑动显着有助于建立和维持微管极性模式在不同区域的神经元。本文的目的是回顾微管在神经元中滑动的知识状态,重点是它的机制基础以及它的功能意义。
Microtubule sliding is an underappreciated mechanism that contributes to the establishment, organization, preservation, and plasticity of neuronal microtubule arrays. Powered by molecular motor proteins and regulated in part by static crosslinker proteins, microtubule sliding is the movement of microtubules relative to other microtubules or to non-microtubule structures such as the actin cytoskeleton. In addition to other important functions, microtubule sliding significantly contributes to the establishment and maintenance of microtubule polarity patterns in different regions of the neuron. The purpose of this article is to review the state of knowledge on microtubule sliding in the neuron, with emphasis on its mechanistic underpinnings as well as its functional significance.
细胞质动力蛋白在微管和神经丝的轴突转运中的作用。
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