Airway Epithelial Innate Immunity.
Airway Epithelial Innate Immunity.
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DOI：
10.3389/fphys.2021.749077
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发表时间：
2021
影响因子：
4
通讯作者：
Dickey BF
中科院分区：
文献类型：
--
作者：
Johnston SL;Goldblatt DL;Evans SE;Tuvim MJ;Dickey BF
除了提供必要的保护屏障外，气道上皮细胞直接感知病原体并做出防御反应。这是先天免疫系统的前线组成部分，对不同的病原体类别具有特异性。它发生在与白细胞的许多相互作用的背景下，但在这里，我们专注于内在的上皮机制。1型免疫应答主要针对细胞内病原体，特别是病毒。突出的刺激包括微生物核酸和从邻近上皮细胞释放的干扰素。上皮细胞反应围绕干扰素敏感基因（ISG）表达的变化，干扰病毒复制，以及进一步诱导干扰素的信号自分泌和旁分泌方式。2型免疫反应主要针对蠕虫和真菌。主要的病原体刺激包括蛋白酶和几丁质，重要的反应包括粘蛋白分泌过多和几丁质酶释放。3型免疫应答主要针对细胞外微生物病原体，包括细菌和真菌，以及在其细胞外感染阶段的病毒。主要的微生物刺激物包括细菌壁组分，如脂肽和内毒素，以及微生物核酸。关键反应是活性氧（ROS）和抗菌肽（AMP）的释放。对于所有这三种类型的反应，旁分泌信号传导到邻近的上皮细胞诱导抵抗感染的广泛领域。通常，除了释放促进局部先天免疫的炎性细胞因子外，上皮效应分子本身也具有信号传导特性。总之，这些上皮机制提供了强大的病原体防御第一线，招募白细胞，并指导适应性免疫反应。
Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. This is a frontline component of the innate immune system with specificity for different pathogen classes. It occurs in the context of numerous interactions with leukocytes, but here we focus on intrinsic epithelial mechanisms. Type 1 immune responses are directed primarily at intracellular pathogens, particularly viruses. Prominent stimuli include microbial nucleic acids and interferons released from neighboring epithelial cells. Epithelial responses revolve around changes in the expression of interferon-sensitive genes (ISGs) that interfere with viral replication, as well as the further induction of interferons that signal in autocrine and paracrine manners. Type 2 immune responses are directed primarily at helminths and fungi. Prominent pathogen stimuli include proteases and chitin, and important responses include mucin hypersecretion and chitinase release. Type 3 immune responses are directed primarily at extracellular microbial pathogens, including bacteria and fungi, as well as viruses during their extracellular phase of infection. Prominent microbial stimuli include bacterial wall components, such as lipopeptides and endotoxin, as well as microbial nucleic acids. Key responses are the release of reactive oxygen species (ROS) and antimicrobial peptides (AMPs). For all three types of response, paracrine signaling to neighboring epithelial cells induces resistance to infection over a wide field. Often, the epithelial effector molecules themselves also have signaling properties, in addition to the release of inflammatory cytokines that boost local innate immunity. Together, these epithelial mechanisms provide a powerful first line of pathogen defense, recruit leukocytes, and instruct adaptive immune responses.
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DOI：
10.1056/nejmra0910061
发表时间：
2010-12-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Fahy JV;Dickey BF
通讯作者：
Dickey BF
DOI：
10.1016/s2213-2600(20)30566-x
发表时间：
2021-05
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Feld JJ;Kandel C;Biondi MJ;Kozak RA;Zahoor MA;Lemieux C;Borgia SM;Boggild AK;Powis J;McCready J;Tan DHS;Chan T;Coburn B;Kumar D;Humar A;Chan A;O'Neil B;Noureldin S;Booth J;Hong R;Smookler D;Aleyadeh W;Patel A;Barber B;Casey J;Hiebert R;Mistry H;Choong I;Hislop C;Santer DM;Lorne Tyrrell D;Glenn JS;Gehring AJ;Janssen HLA;Hansen BE
通讯作者：
Hansen BE
影响因子：
15.3
作者：
Campbell, Laura;Hepworth, Matthew R.;Grencis, Richard K.
通讯作者：
Grencis, Richard K.
DOI：
10.1164/rccm.201312-2235oc
发表时间：
2014-07-15
影响因子：
24.7
作者：
Djukanovic, Ratko;Harrison, Tim;Monk, Phillip
通讯作者：
Monk, Phillip
生物化学。在坚实的地面上行走。
DOI：
10.1126/science.1227091
发表时间：
2012-08-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dickey BF
通讯作者：
Dickey BF