Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence.
Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence.
复制标题
DOI：
10.1007/s11912-020-0888-x
复制
发表时间：
2020-02-12
影响因子：
4.7
通讯作者：
Matsuo K
中科院分区：
文献类型：
--
作者：
Matsuzaki S;Klar M;Mikami M;Shimada M;Grubbs BH;Fujiwara K;Roman LD;Matsuo K
回顾和讨论目前基于手术和放射治疗的IIB期宫颈癌治疗策略的证据。最近，两个随机对照试验比较了新辅助化疗加根治性子宫切除术(NACT+RH)和同期放化疗(CCRT)治疗IB3-IIB期宫颈癌的疗效。当这些研究结合在一起时(N=1259)，NACT+RH与CCRT的结果相比，无病生存期较短[风险比(HR)1.36，95%可信区间(CI)1.13~1.64]，但总体生存率相似(HR 1.11，95%CI 0.90~1.36)。对IIB期宫颈癌的分期分析显示，NACT+RH组的无瘤生存率显著低于CCRT组(HR 1.90，95%CI 1.25~2.89)，而IB3-IIA期宫颈癌的无瘤生存率无显著差异。根据最近I级证据的结果，IIB期宫颈癌的标准治疗方法仍然是CCRT。
To review and discuss the present evidence of surgery- and radiation-based treatment strategies for stage IIB cervical cancer. Recently, two randomized controlled trials compared the efficacy of neoadjuvant chemotherapy followed by radical hysterectomy (NACT + RH) with that of concurrent chemoradiotherapy (CCRT) for stage IB3–IIB cervical cancer. When these studies were combined (N = 1259), NACT + RH was associated with a shorter disease-free survival [hazard ratio (HR) 1.36, 95% confidence interval (CI) 1.13–1.64], but with a similar overall survival (HR 1.11, 95% CI 0.90–1.36) when compared with the findings for CCRT. Stage-specific analysis for stage IIB cervical cancer demonstrated that disease-free survival was significantly worse with NACT + RH than with CCRT (HR 1.90, 95% CI 1.25–2.89); however, no significant difference was observed for stage IB3–IIA cervical cancer. Based on the results of recent level I evidence, the standard treatment for stage IIB cervical cancer remains CCRT.
登录
查看更多内容
影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
3.5
作者：
Cibula, David;Poetter, Richard;Raspollini, Maria Rosaria
通讯作者：
Raspollini, Maria Rosaria
根治性子宫切除术联合辅助放疗与根治性放疗治疗FIGO IIB期宫颈癌的比较
影响因子：
3.8
作者：
Chai Y;Wang T;Wang J;Yang Y;Gao Y;Gao J;Gao S;Wang Y;Zhou X;Liu Z
通讯作者：
Liu Z
影响因子：
4.7
作者：
Chen, Huijun;Liang, Chuan;Wu, Xufeng
通讯作者：
Wu, Xufeng