αKlotho and vascular calcification: an evolving paradigm.
αKlotho and vascular calcification: an evolving paradigm.
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αKlotho 和血管钙化：一个不断发展的范例。
DOI：
10.1097/01.mnh.0000447024.97464.a3
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发表时间：
2014-07
影响因子：
3.2
通讯作者：
Moe OW
中科院分区：
文献类型：
--
作者：
Hu MC;Kuro-o M;Moe OW
心血管疾病仍然是导致慢性肾脏疾病（CKD）死亡的最严重因素。尽管传统的危险因素在CKD中普遍存在，但心肌病和血管病变都可能由尿毒症状态特有的病理生理机制引起。CKD是一种系统性α - klotho缺乏的状态。虽然αKlotho的分子作用机制尚不清楚，但αKlotho的下游靶点和生物学功能却具有惊人的多效性。新出现的文献将αKlotho与尿毒症血管病变联系起来。α - klotho在血管中的表达由于数据矛盾而存在争议。无论α - klotho是循环蛋白还是常驻蛋白，α - klotho水平的变化与血管病理（包括血管钙化）有关，α - klotho在体外对内皮细胞和血管平滑肌细胞有直接作用，保护细胞和防止矿化。在尿毒症血管病变中，αKlotho可以作为潜在的预后生物标志物和生物治疗剂，因此了解αKlotho对整体内皮-血管平滑肌网络而不是单个细胞类型的致病作用至关重要。
Cardiovascular disease remains the single most serious contributor to mortality in chronic kidney disease (CKD). Although conventional risk factors are prevalent in CKD, both cardiomyopathy and vasculopathy can be caused by pathophysiologic mechanisms specific to the uremic state. CKD is a state of systemic αKlotho deficiency. While the molecular mechanism of action of αKlotho is not well understood, the downstream targets and biologic functions of αKlotho are astonishingly pleiotropic. An emerging body of literature links αKlotho to uremic vasculopathy. The expression of αKlotho in the vasculature is controversial due to conflicting data. Regardless of whether αKlotho acts a circulating or resident protein, there are good data associating changes in αKlotho levels with vascular pathology including vascular calcification and in vitro data of direct action of αKlotho on both the endothelium and vascular smooth muscle cells in terms of cytoprotection and prevention of mineralization. It is critical to understand the pathogenic role of αKlotho on the integral endothelium-vascular smooth muscle network rather than each cell type in isolation in uremic vasculopathy, as αKlotho can serve as a potential prognostic biomarker and a biological therapeutic agent.
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影响因子：
19.6
作者：
通讯作者：
--
影响因子：
3.7
作者：
Kitagawa M;Sugiyama H;Morinaga H;Inoue T;Takiue K;Ogawa A;Yamanari T;Kikumoto Y;Uchida HA;Kitamura S;Maeshima Y;Nakamura K;Ito H;Makino H
通讯作者：
Makino H
DOI：
10.2215/cjn.02700313
发表时间：
2013-11-07
影响因子：
9.8
作者：
Karalliedde, Janaka;Maltese, Giuseppe;Gnudi, Luigi
通讯作者：
Gnudi, Luigi
影响因子：
--
作者：
Hu, Ming Chang;Kuro-o, Makoto;Moe, Orson W.
通讯作者：
Moe, Orson W.
影响因子：
18.2
作者：
Hu MC;Shiizaki K;Kuro-o M;Moe OW
通讯作者：
Moe OW