Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
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DOI：
10.1146/annurev-physiol-030212-183727
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发表时间：
2013
影响因子：
18.2
通讯作者：
Moe OW
中科院分区：
文献类型：
--
作者：
Hu MC;Shiizaki K;Kuro-o M;Moe OW
陆生脊椎动物以钙磷为基础的内骨骼代谢活跃，并不断重塑，这就要求整个生物体的钙磷动态平衡涉及到多个器官的矿物质流动和内分泌干扰。成纤维细胞生长因子-Klotho内分泌网络集中体现了系统生物学的复杂性，特别是FGF23-αKlotho轴突出了骨架的概念，该骨架控制着动态平衡的主开关，而不是迄今设想的被动靶器官。除了作为FGF23的辅助受体外，αKlotho还作为一种内分泌物质循环，具有多种作用。本文综述了复杂的FGF23-αKlotho网络的生理调节和功能的最新数据。慢性肾脏疾病是一种常见的病理生理状态，在这种状态下，FGF23-αKlotho是一个多器官内分泌网络，处于自我放大的漩涡中，导致极其严重的器官功能障碍，导致其发病率和死亡率。
The metabolically active and perpetually remodeling calcium phosphate–based endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and phosphate homeostasis that involves multiple organs in terms of mineral flux and endocrine cross talk. The fibroblast growth factor (FGF)-Klotho endocrine networks epitomize the complexity of systems biology, and specifically, the FGF23-αKlotho axis highlights the concept of the skeleton holding the master switch of homeostasis rather than a passive target organ as hitherto conceived. Other than serving as a coreceptor for FGF23, αKlotho circulates as an endocrine substance with a multitude of effects. This review covers recent data on the physiological regulation and function of the complex FGF23-αKlotho network. Chronic kidney disease is a common pathophysiological state in which FGF23-αKlotho, a multiorgan endocrine network, is deranged in a self-amplifying vortex resulting in organ dysfunction of the utmost severity that contributes to its morbidity and mortality.
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