Effects of stimulus pulse rate on somatosensory adaptation in the human cortex.
Effects of stimulus pulse rate on somatosensory adaptation in the human cortex.
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刺激脉冲率对人体皮层体感觉适应的影响。
DOI：
10.1016/j.brs.2022.05.021
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发表时间：
2022-07
影响因子：
7.7
通讯作者：
Gaunt RA
中科院分区：
文献类型：
--
作者：
Hughes CL;Flesher SN;Gaunt RA
体感皮层的皮质内微刺激（ICMS）可以恢复神经系统疾病患者的感觉。然而，人们对 ICMS 的许多方面知之甚少，包括随着时间的推移刺激对感知强度的影响。在这里，我们评估了 ICMS 在人类参与者的体感皮层中引起的触觉感知如何随着时间的推移而适应。我们向体感皮层提供连续和间歇性 ICMS，并评估了人类参与者随时间报告的触觉感知强度。实验进行了大约一年，并使用线性混合效应模型来评估显着性。高频的连续刺激会导致强度迅速下降，而低频刺激会在较长时间内维持感知强度。突发调制刺激延长了强度开始降低之前的时间，但所有方案最终都导致在一分钟内完全感觉丧失。刺激序列之间有几秒钟的间歇性刺激范例会引起间歇性知觉，并导致许多电极上的强度降低，但在超过三分钟的刺激后从未导致感觉消失。每个脉冲串之间较长的休息时间导致刺激引起的感知强度有所恢复。对于几个电极来说，间歇性刺激对感知强度几乎没有影响。间歇性 ICMS 范式在维持感知方面更有效。鉴于短暂的神经活动在机械接触开始和结束期间主导体感皮层的反应，在这些时间提供短暂的刺激序列可能更接近地代表自然皮层活动，并且具有延长在较长时间内唤起感觉的能力的额外好处。
Intracortical microstimulation (ICMS) of the somatosensory cortex can restore sensation to people with neurological diseases. However, many aspects of ICMS are poorly understood, including the effect of stimulation on percept intensity over time. Here, we evaluate how tactile percepts, evoked by ICMS in the somatosensory cortex of a human participant adapt over time. We delivered continuous and intermittent ICMS to the somatosensory cortex and assessed the reported intensity of tactile percepts over time in a human participant. Experiments were conducted over approximately one year and linear mixed effects models were used to assess significance. Continuous stimulation at high frequencies led to rapid decreases in intensity, while low frequency stimulation maintained percept intensity for longer periods. Burst-modulated stimulation extended the time before the intensity began to decrease, but all protocols ultimately resulted in complete sensation loss within one minute. Intermittent stimulation paradigms with several seconds between stimulus trains evoked intermittent percepts and also led to decreases in intensity on many electrodes, but never resulted in extinction of the sensation after over three minutes of stimulation. Longer breaks between each pulse train resulted in some recovery in the intensity of the stimulus-evoked percepts. For several electrodes, intermittent stimulation had almost no effect on the perceived intensity. Intermittent ICMS paradigms were more effective at maintaining percepts. Given that transient neural activity dominates the response in somatosensory cortex during mechanical contact onsets and offsets, providing brief stimulation trains at these times may more closely represent natural cortical activity and have the additional benefit of prolonging the ability to evoke sensations over longer time periods.
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DOI：
10.1007/978-3-319-64373-1_5
发表时间：
2017-01-01
期刊：
BRAIN-COMPUTER INTERFACE RESEARCH: A STATE-OF-THE-ART SUMMARY 6
影响因子：
--
作者：
Flesher, Sharlene;Downey, John;Gaunt, Robert
通讯作者：
Gaunt, Robert
影响因子：
25
作者：
Dadarlat, Maria C.;O'Doherty, Joseph E.;Sabes, Philip N.
通讯作者：
Sabes, Philip N.
影响因子：
4
作者：
Kumaravelu K;Tomlinson T;Callier T;Sombeck J;Bensmaia SJ;Miller LE;Grill WM
通讯作者：
Grill WM
影响因子：
2.4
作者：
GOBLE, AK;HOLLINS, M
通讯作者：
HOLLINS, M
影响因子：
4
作者：
Graczyk EL;Delhaye BP;Schiefer MA;Bensmaia SJ;Tyler DJ
通讯作者：
Tyler DJ