Breakfast consumption induces retarded release of chlorogenic acid metabolites in humans
Breakfast consumption induces retarded release of chlorogenic acid metabolites in humans
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早餐摄入会导致人体绿原酸代谢物的延迟释放
DOI：
10.1007/s00217-016-2793-y
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发表时间：
2017
影响因子：
3.3
通讯作者：
E. Richling
中科院分区：
文献类型：
--
作者：
D. Scherbl;M. Renouf;C. Marmet;L. Poquet;I. Cristiani;S. Dahbane;S. Emady-Azar;J. Sauser;J. Galan;E. Richling
咖啡是人体营养中绿原酸（CGA）的主要来源。在这项研究中，一个主要的兴趣点是同时食用咖啡和食物是否会影响CGA的吸收和生物利用度。14名健康的参与者饮用纯速溶咖啡（T1），或咖啡与高碳水化合物（T2）或高脂肪餐（T3）。所有志愿者摄入相同数量的CGA（3.1 mg CGA/kg bw），并分别在摄入后15 h和24 h的不同时间点采集血液和尿液样本。使用HPLC-ESI-MS/MS测定现有CGA及其各自的代谢物浓度。曲线下面积（AUC）是每次处理后收集的血浆样品中CGA量的量度。我们观察到纯速溶咖啡消费（T1）后的CGA生物利用度显着高于额外消费的高脂肪餐（T3）。然而，纯咖啡（T1）和咖啡加高碳水化合物餐（T2）之间的CGA生物利用度差异无统计学意义。当T3样品与T2样品比较时，后一观察结果成立。当代谢物分为各自的类别时，仅在某些类别中观察到AUC总和的显著差异，而在治疗组之间未观察到显著差异。数据未显示总生物利用度的差异，但揭示了释放动力学的差异。早餐的共同摄入有利于结肠代谢物的缓慢和持续释放，而非代谢咖啡成分出现在咖啡消费后的第一个小时。在24小时内采集的尿液样本未显示治疗组之间的任何统计学显著差异。仅在饮用咖啡后前6小时内收集的样本显示，T1和T3后收集的尿液样本中的CGA量显著大于额外饮用碳水化合物（T2）的量。早餐对咖啡中CGA的吸收没有显著影响。然而，观察到胃肠道通过时间和血浆代谢产物组成发生变化。因此，早餐消费诱导延迟释放人体中的绿原酸代谢产物。
Coffee is the main source of chlorogenic acids (CGAs) in human nutrition. In this study, one main point of interest was whether the simultaneous consumption of coffee and food affects the absorption and bioavailability of CGAs. Fourteen healthy participants consumed pure instant coffee (T1), or coffee with either a high-carbohydrate (T2) or a high-fat meal (T3). All volunteers consumed the same quantity of CGAs (3.1 mg CGA/kg bw), and blood and urine samples were collected at various time points for up to 15 h and 24 h after consumption, respectively. Existing CGAs, and their respective metabolite concentrations, were determined using HPLC–ESI-MS/MS. The area under the curve (AUC) was the measure of CGA quantity in plasma samples collected after each treatment. We observed significantly greater CGA bioavailability after pure instant coffee consumption (T1) than with an additional consumption of a high-fat meal (T3). However, the difference in CGA bioavailability between pure coffee (T1) and coffee plus high-carbohydrate meal (T2) was not statistically significant. The latter observation held true when T3-samples were compared with T2-samples. When the metabolites were split into their respective classes, significant differences in the sums of AUC were observed only for some classes, and not among the treatments. Data did not show differences in the total bioavailability, but revealed differences in the kinetic of release. The co-ingestion of breakfast favored a slow and continuous release of colonic metabolites in contrast to the non-metabolized coffee components appearing in the first hour after coffee consumption. Urine samples collected over 24 h did not show any statistically significant differences among the treatments. Only samples collected within the first 6 h post-coffee consumption showed that the CGA quantities in urine samples collected after T1 and T3 were significantly greater than quantities with an additional consumption of carbohydrates (T2). Breakfast had no significant effect on CGA absorption from coffee. However, a shift in gastrointestinal transit time and in the plasma metabolite composition was observed. So breakfast consumption induces retarded release of chlorogenic acid metabolites in humans.
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DOI：
--
发表时间：
2006
期刊：
J Agric. Food Chem. 54
影响因子：
--
作者：
Konishi Y;Zhao Z;Shimizu M
通讯作者：
Shimizu M
影响因子：
6.1
作者：
Konishi, Y;Hitomi, Y;Yoshioka, E
通讯作者：
Yoshioka, E
影响因子：
6.1
作者：
Jacobsen, C;Schwarz, K;Adler-Nissen, J
通讯作者：
Adler-Nissen, J
影响因子：
3.9
作者：
Poquet, Laure;Clifford, Michael N.;Williamson, Gary
通讯作者：
Williamson, Gary
影响因子：
6
作者：
Erk, Thomas;Hauser, Johanna;Richling, Elke
通讯作者：
Richling, Elke