Multimodal thrombectomy device for treatment of acute deep venous thrombosis.
Multimodal thrombectomy device for treatment of acute deep venous thrombosis.
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DOI：
10.1038/s41598-022-09001-6
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发表时间：
2022-03-28
影响因子：
4.6
通讯作者：
Zayed MA
中科院分区：
文献类型：
--
作者：
Ismail U;Rowe RA;Cashin J;Genin GM;Zayed MA
深静脉血栓形成（DVT）是一种潜在的致命的医疗条件，治疗费用昂贵，每年影响成千上万的美国人。DVT的特征是在身体的深静脉系统内形成血块。如果DVT移位，则可导致静脉血栓栓塞（VTE）和肺栓塞（PE），这两者都可导致严重的发病率或死亡。目前DVT的治疗选择在有效性和安全性方面都是有限的，部分原因是DVT的治疗不能局限于限定的隔离治疗区。因此，我们开发并测试了一种新型血栓切除术器械，该器械能够在碎裂和排空期间将DVT隔离到规定的治疗区域。我们观察到，与同品种血栓切除术器械相比，隔离入路减少了离体血栓切除术期间的远端DVT栓塞。隔离方法还促进了等容输注和抽吸，能够清除隔离治疗区，而不会显著影响静脉壁直径。结果表明，我们的新设备使用隔离治疗有希望治疗高风险的大容量DVT。
Deep vein thrombosis (DVT) is a potentially deadly medical condition that is costly to treat and impacts thousands of Americans every year. DVT is characterized by the formation of blood clots within the deep venous system of the body. If a DVT dislodges it can lead to venous thromboembolism (VTE) and pulmonary embolism (PE), both of which can lead to significant morbidity or death. Current treatment options for DVT are limited in both effectiveness and safety, in part because the treatment of the DVT cannot be confined to a defined sequestered treatment zone. We therefore developed and tested a novel thrombectomy device that enables the sequesteration of a DVT to a defined treatment zone during fragmentation and evacuation. We observed that, compared to a predicate thrombectomy device, the sequestered approach reduced distal DVT embolization during ex vivo thrombectomy. The sequestered approach also facilitated isovolumetric infusion and suction that enabled clearance of the sequestered treatment zone without significantly impacting vein wall diameter. Results suggest that our novel device using sequestered therapy holds promise for the treatment of high risk large-volume DVTs.
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影响因子：
15.1
作者：
Vincent, Jean-Louis;Jaschinski, Ulrich;Sakr, Yasser
通讯作者：
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影响因子：
2.8
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DOI：
10.1016/s1051-0443(07)61465-1
发表时间：
2000-02-01
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Zierler, Brenda K.