Resting-state global brain activity affects early β-amyloid accumulation in default mode network.
Resting-state global brain activity affects early β-amyloid accumulation in default mode network.
复制标题
DOI：
10.1038/s41467-023-43627-y
复制
发表时间：
2023-11-27
影响因子：
16.6
通讯作者：
Liu, Xiao
中科院分区：
文献类型：
--
作者：
Han, Feng;Liu, Xufu;Mailman, Richard B;Huang, Xuemei;Liu, Xiao
目前尚不清楚为什么β-淀粉样蛋白（A β）斑块，阿尔茨海默病（AD）的标志性病理，首先积累在默认模式网络（DMN），AD诊断前几年。最近，静息状态下的低频（<0.1 Hz）全球脑活动与AD有关，可能是由于其在胶质淋巴清除中的作用。我们发现，在A β病理早期，DMN中的A β优先蓄积与相同区域的整体脑活动优先减少有关。这可以部分地解释为它不能作为传播波到达这些区域。总之，这些发现强调了静息态全脑活动在DMN早期优先A β沉积中的重要作用。为什么β-淀粉样蛋白斑块在阿尔茨海默病诊断之前最初在皮层的默认模式网络中积累尚不清楚。在这里，作者表明，这种积累与这些区域的全球大脑活动减少有关。
It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer’s disease (AD), first accumulates cortically in the default mode network (DMN), years before AD diagnosis. Resting-state low-frequency ( < 0.1 Hz) global brain activity recently was linked to AD, presumably due to its role in glymphatic clearance. Here we show that the preferential Aβ accumulation in the DMN at the early stage of Aβ pathology was associated with the preferential reduction of global brain activity in the same regions. This can be partly explained by its failure to reach these regions as propagating waves. Together, these findings highlight the important role of resting-state global brain activity in early preferential Aβ deposition in the DMN. Why β-amyloid plaque initially accumulates in the default mode network of the cortex before Alzheimer’s disease diagnosis is not known. Here, the authors show that this accumulation is associated with a reduction of global brain activity in these regions.
DOI：
10.1016/j.nicl.2022.102952
发表时间：
2022
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
van Balkom TD;van den Heuvel OA;Berendse HW;van der Werf YD;Vriend C
通讯作者：
Vriend C