Eight-week multi-domain cognitive training does not impact large-scale resting-state brain networks in Parkinson's disease.
Eight-week multi-domain cognitive training does not impact large-scale resting-state brain networks in Parkinson's disease.
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DOI：
10.1016/j.nicl.2022.102952
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Vriend C
中科院分区：
文献类型：
--
作者：
van Balkom TD;van den Heuvel OA;Berendse HW;van der Werf YD;Vriend C
认知训练不能增强帕金森病患者的静息状态大脑网络。干预的效果可能是针对相关的前额叶脑连接。未来的研究应侧重于特定认知亚群的认知训练。有荟萃分析证据表明认知训练（CT）对帕金森病（PD）的疗效。我们进行了一项随机对照试验，发现CT对PD患者的执行功能和处理速度有很小的积极影响（ntotal = 140）。在这项研究中，我们评估了CT对整个研究人群（nmri = 86）的脑网络连通性和拓扑结构的影响。参与者被随机分为在线多域CT组和主动对照组，并在8周内进行24次干预。静息状态功能MRI扫描除了广泛的临床和神经心理学评估干预前后。符合我们预先注册的分析计划（osf）。Io /3st82)，我们计算了“认知”静息状态网络与全脑和子网络水平计算的拓扑结果之间的连通性。我们使用混合模型分析评估干预后的组间差异，并使用重复测量相关分析分析网络与认知表现变化之间的关系。最终分析样本包括71名参与者（n CT = 37）。干预后，网络间连通性和网络拓扑结果没有组间差异。神经网络与神经心理表现变化之间没有关联。CT增加隔离网络拓扑在一个小的子样本的认知完整的参与者。事后节点分析显示，干预后CT组的背前扣带皮层和背外侧前额叶皮层的连通性增强。结果表明，8周的计算机CT没有大规模的脑网络效应，而是认知功能关键区域的局部连通性变化，这可能反映了干预的具体效果。
Cognitive training does not enhance resting-state brain networks in Parkinson’s disease. Effects of the intervention rather may target relevant prefrontal brain connections. Future research should focus on cognitive training in specific cognitive subgroups. There is meta-analytic evidence for the efficacy of cognitive training (CT) in Parkinson’s disease (PD). We performed a randomized controlled trial where we found small positive effects of CT on executive function and processing speed in individuals with PD (ntotal = 140). In this study, we assessed the effects of CT on brain network connectivity and topology in a subsample of the full study population (nmri = 86). Participants were randomized into an online multi-domain CT and an active control condition and performed 24 sessions of either intervention in eight weeks. Resting-state functional MRI scans were acquired in addition to extensive clinical and neuropsychological assessments pre- and post-intervention. In line with our preregistered analysis plan (osf.io/3st82), we computed connectivity between ‘cognitive’ resting-state networks and computed topological outcomes at the whole-brain and sub-network level. We assessed group differences after the intervention with mixed-model analyses adjusting for baseline performance and analyzed the association between network and cognitive performance changes with repeated measures correlation analyses. The final analysis sample consisted of 71 participants (n CT = 37). After intervention there were no group differences on between-network connectivity and network topological outcomes. No associations between neural network and neuropsychological performance change were found. CT increased segregated network topology in a small sub-sample of cognitively intact participants. Post-hoc nodal analyses showed post-intervention enhanced connectivity of both the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex in the CT group. The results suggest no large-scale brain network effects of eight-week computerized CT, but rather localized connectivity changes of key regions in cognitive function, that potentially reflect the specific effects of the intervention.
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影响因子：
3.2
作者：
Díez-Cirarda M;Ojeda N;Peña J;Cabrera-Zubizarreta A;Lucas-Jiménez O;Gómez-Esteban JC;Gómez-Beldarrain MÁ;Ibarretxe-Bilbao N
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Ibarretxe-Bilbao N
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6
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影响因子：
29.9
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Bertolero, Maxwell A.;Yeo, B. T. Thomas;D'Esposito, Mark
通讯作者：
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影响因子：
9.9
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