Assessing the role of ¹⁸F-FDG PET and ¹⁸F-FDG PET/CT in the diagnosis of soft tissue musculoskeletal malignancies: a systematic review and meta-analysis.
Assessing the role of ¹⁸F-FDG PET and ¹⁸F-FDG PET/CT in the diagnosis of soft tissue musculoskeletal malignancies: a systematic review and meta-analysis.
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DOI：
10.1007/s00259-015-3242-z
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发表时间：
2016-05
影响因子：
9.1
通讯作者：
Macapinlac, Homer A.
中科院分区：
文献类型：
--
作者：
Etchebehere, Elba C.;Hobbs, Brian P.;Milton, Denai R.;Malawi, Osama;Patel, Shreyaskumar;Benjamin, Robert S.;Macapinlac, Homer A.
12年前，一项荟萃分析评估了18F-FDG PET在评估肌肉骨骼软组织病变(MsSTL)中的诊断性能。目前，PET/CT已经取代了PET成像，但目前还没有关于PET/CT在MsSTL诊断中的应用的荟萃分析，也没有将其与PET进行比较。因此，我们进行了一项荟萃分析，以确定目前18F-FDG PET/CT的诊断性能，并确定与PET相比是否有附加值。应用计算机检索MEDLINE PubMed、Cochrane图书馆和EMBASE，检索1996-2015年3月的英文文献。研究探索18F-FDG PET/CT(或专用PET)与组织病理学诊断MsSTL的准确性。我们的荟萃分析包括14篇文章，包括755名患者的757个软组织病变。恶性肿瘤451例(60%)，良性病变306例。18F-FDGPET/CT诊断MsSTL的灵敏度、特异度、准确度、阳性预测值和阴性预测值分别为0.96(0.90，1.00)，0.77(0.67，0.86)，0.88(0.85，0.91)，0.86(0.78，0.94)和0.91(0.83，0.99)。AUC的后验均值(95%HPD间期)为0.92(0.88，0.96)。与专用PET相比，PET/CT具有更高的特异性、准确性和阳性预测值(分别为0.85、0.89和0.91vs0.71、0.85和0.82)。18F-FDG PET/CT和专用PET对MsSTL的诊断准确率均较高。PET/CT较PET更准确、更特异，阳性预测值更高。
Twelve years ago a meta-analysis evaluated the diagnostic performance of 18F-FDG PET in assessing musculoskeletal soft tissue lesions (MsSTL). Currently, PET/CT has substituted PET imaging however there has not been any published meta-analysis on the use of PET/CT or a comparison of PET/CT with PET in the diagnosis of MsSTL. Therefore, we conducted a meta-analysis to identify the current diagnostic performance of 18F-FDG PET/CT and determine if there is added value when compared to PET. A systematic review of English articles using MEDLINE PubMed, the Cochrane Library and EMBASE were searched from 1996 to March 2015. Studies exploring the diagnostic accuracy of 18F-FDG PET/CT (or dedicated PET) compared to histopathology in patients with MsSTL undergoing investigation for malignancy were included. Our meta-analysis included 14 articles composed of 755 patients with 757 soft tissue lesions. There were 451 (60%) malignant tumors and 306 benign lesions. The 18F-FDG PET/CT (and dedicated PET) mean sensitivity, specificity, accuracy, positive and negative predictive values for diagnosing MsSTL was 0.96 (0.90, 1.00), 0.77 (0.67, 0.86), 0.88 (0.85, 0.91), 0.86 (0.78, 0.94) and 0.91 (0.83, 0.99), respectively. The posterior mean (95% HPD interval) for the AUC was 0.92 (0.88, 0.96). PET/CT had higher specificity, accuracy and positive predictive value when compared to a dedicated PET (0.85, 0.89 and 0.91 vs 0.71, 0.85 and 0.82, respectively). 18F-FDG PET/CT and dedicated PET are both highly accurate in the diagnosis of MsSTL. PET/CT is more accurate, specific and has a higher positive predictive value than PET.
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影响因子：
2.1
作者：
Panzarella, MJ;Naqvi, AH;Damron, TA
通讯作者：
Damron, TA
影响因子：
9.3
作者：
Gerth, Hans U.;Juergens, Kai U.;Franzius, Christiane
通讯作者：
Franzius, Christiane
影响因子：
2.1
作者：
Hong, Sun-pyo;Lee, Seung Eun;Choi, Joon Young
通讯作者：
Choi, Joon Young
影响因子：
10.6
作者：
Rest, CCL;Botton, E;Visvikis, D
通讯作者：
Visvikis, D
DOI：
10.1186/bcr3355
发表时间：
2013-01-22
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Landis MD;Lehmann BD;Pietenpol JA;Chang JC
通讯作者：
Chang JC