Causal associations between body fat accumulation and COVID-19 severity: A Mendelian randomization study.
Causal associations between body fat accumulation and COVID-19 severity: A Mendelian randomization study.
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身体脂肪积累与 COVID-19 严重程度之间的因果关系：孟德尔随机研究。
DOI：
10.3389/fendo.2022.899625
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
之前的研究报告了以体重指数衡量的肥胖与2019年冠状病毒疾病(新冠肺炎)之间的关联。然而，BMI只根据身高和体重计算，不能区分身体脂肪质量和脱脂质量。因此，目前还不清楚这两项指标中是否有一项或两项在肥胖和新冠肺炎之间起到了中介作用。在这里，我们使用孟德尔随机化(MR)来比较体脂质量和脱脂质量与新冠肺炎严重程度之间的独立因果关系。我们在来自英国生物库的454,137和454,850名欧洲血统个体中发现了与体脂质量和脱脂质量相关的单核苷酸多态。然后，我们进行了两个样本的磁共振检查，以确定它们对严重新冠肺炎(病例：4,792例；对照：1,054,664例)的影响。我们发现，体脂肪质量每增加一个标准差与严重的新冠肺炎相关(优势比(OR)体脂质量=1.6 1，95%可信区间[CI]：1.2 8~2.0 4，P=5.5 1×10-5；OR体脂质量=1.31，95%CI：0.99~1.74，P=5.77×10-2)。考虑到体脂质量和脱脂质量在遗传上相互关联(r=0.64)，我们进一步使用多变量MR对体脂质量和脱脂质量的独立因果效应进行了评估，发现只有体脂质量与严重的新冠肺炎独立相关(OR体脂肪质量=2.91，95%CI：1.71~4.96，P=8.85×10-5；OR体脂肪质量=1.0 2，95%CI：0.61~1.67，P=0.945)。综上所述，本研究论证了体脂堆积对新冠肺炎严重程度的因果影响，并表明影响新冠肺炎与肥胖关系的生物学途径可能是通过体脂质量来调节的。
Previous studies reported associations between obesity measured by body mass index (BMI) and coronavirus disease 2019 (COVID-19). However, BMI is calculated only with height and weight and cannot distinguish between body fat mass and fat-free mass. Thus, it is not clear if one or both of these measures are mediating the relationship between obesity and COVID-19. Here, we used Mendelian randomization (MR) to compare the independent causal relationships of body fat mass and fat-free mass with COVID-19 severity. We identified single nucleotide polymorphisms associated with body fat mass and fat-free mass in 454,137 and 454,850 individuals of European ancestry from the UK Biobank, respectively. We then performed two-sample MR to ascertain their effects on severe COVID-19 (cases: 4,792; controls: 1,054,664) from the COVID-19 Host Genetics Initiative. We found that an increase in body fat mass by one standard deviation was associated with severe COVID-19 (odds ratio (OR)body fat mass = 1.61, 95% confidence interval [CI]: 1.28–2.04, P = 5.51 × 10-5; ORbody fat-free mass = 1.31, 95% CI: 0.99–1.74, P = 5.77 × 10-2). Considering that body fat mass and fat-free mass were genetically correlated with each other (r = 0.64), we further evaluated independent causal effects of body fat mass and fat-free mass using multivariable MR and revealed that only body fat mass was independently associated with severe COVID-19 (ORbody fat mass = 2.91, 95% CI: 1.71–4.96, P = 8.85 × 10-5 and ORbody fat-free mass = 1.02, 95%CI: 0.61–1.67, P = 0.945). In summary, this study demonstrates the causal effects of body fat accumulation on COVID-19 severity and indicates that the biological pathways influencing the relationship between COVID-19 and obesity are likely mediated through body fat mass.
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影响因子：
5.2
作者：
Lin X;Li H
通讯作者：
Li H
影响因子：
64.8
作者：
COVID-19 Host Genetics Initiative
通讯作者：
COVID-19 Host Genetics Initiative
DOI：
10.1038/s41366-021-01054-3
发表时间：
2022-05
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Gao M;Wang Q;Piernas C;Astbury NM;Jebb SA;Holmes MV;Aveyard P
通讯作者：
Aveyard P
DOI：
10.1097/ede.0000000000000161
发表时间：
2014-11
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Burgess S;Davies NM;Thompson SG;EPIC-InterAct Consortium
通讯作者：
EPIC-InterAct Consortium
影响因子：
1.6
作者：
Cecelja M;Lewis CM;Shah AM;Chowienczyk P
通讯作者：
Chowienczyk P