Cancer invasion into musculature: Mechanics, molecules and implications.
Cancer invasion into musculature: Mechanics, molecules and implications.
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癌症入侵肌肉：力学，分子和影响。
DOI：
10.1016/j.semcdb.2018.07.014
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发表时间：
2019-09
影响因子：
7.3
通讯作者：
Wolf K
中科院分区：
文献类型：
--
作者：
Beunk L;Brown K;Nagtegaal I;Friedl P;Wolf K
肿瘤沿周围无肿瘤组织的结构间期沿着侵袭是肿瘤进展过程中的关键过程。肿瘤细胞在富含细胞外基质（ECM）的结缔组织中迁移的机制一直受到关注，然而，缺乏对肿瘤侵入更高结构复杂性的组织（例如肌肉组织）的全面理解。癌症患者的肌肉浸润通常与破坏性生长和预后恶化有关。在这里，我们回顾了平滑肌和骨骼肌组织的生化，几何和机械线索及其相关性的指导癌细胞的入侵。作为综合概念，肌外膜、肌周膜和肌内膜的富含ECM的肌肉组织表面沿着动态肌细胞之间的界面提供了裂缝状的密闭空间，这提供了引导癌细胞迁移的分子和物理线索，可能对癌症的进展做出贡献。
Tumor invasion along structural interphases of surrounding tumor-free tissue represents a key process during tumor progression. Much attention has been devoted to mechanisms of tumor cell migration within extracellular matrix (ECM)-rich connective tissue, however a comprehensive understanding of tumor invasion into tissue of higher structural complexity, such as muscle tissue, is lacking. Muscle invasion in cancer patients is often associated with destructive growth and worsened prognosis. Here, we review biochemical, geometrical and mechanical cues of smooth and skeletal muscle tissues and their relevance for guided invasion of cancer cells. As integrating concept, muscle-organizing ECM-rich surfaces of the epi-, peri- and endomysium provide cleft-like confined spaces along interfaces between dynamic muscle cells, which provide molecular and physical cues that guide migrating cancer cells, forming a possible contribution to cancer progression.
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影响因子：
64.5
作者：
Cheung KJ;Gabrielson E;Werb Z;Ewald AJ
通讯作者：
Ewald AJ
影响因子：
4.8
作者：
Balzer, Eric M.;Tong, Ziqiu;Konstantopoulos, Konstantinos
通讯作者：
Konstantopoulos, Konstantinos
影响因子：
5.5
作者：
Carey, Shawn P.;Rahman, Aniqua;Reinhart-King, Cynthia A.
通讯作者：
Reinhart-King, Cynthia A.
影响因子：
4.6
作者：
Benias, Petros C.;Wells, Rebecca G.;Theise, Neil D.
通讯作者：
Theise, Neil D.
影响因子：
3.5
作者：
DUANCE, VC;RESTALL, DJ;BAILEY, AJ
通讯作者：
BAILEY, AJ