Serum trimethylamine-N-oxide is associated with incident type 2 diabetes in middle-aged and older adults: a prospective cohort study.
Serum trimethylamine-N-oxide is associated with incident type 2 diabetes in middle-aged and older adults: a prospective cohort study.
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DOI：
10.1186/s12967-022-03581-7
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发表时间：
2022-08-18
影响因子：
7.4
通讯作者：
Zhu, Hui-lian
中科院分区：
文献类型：
--
作者：
Li, Shu-yi;Chen, Si;Lu, Xiao-ting;Fang, Ai-ping;Chen, Yu-ming;Huang, Rong-zhu;Lin, Xin-lei;Huang, Zi-hui;Ma, Jing-fei;Huang, Bi-xia;Zhu, Hui-lian
氧化三甲胺（TMAO）在糖尿病发展中的作用仍存在争议，前瞻性数据很少。我们的目的是调查血清TMAO与中老年2型糖尿病发病之间的关系。本研究基于广州营养与健康研究（GNHS），这是一项在中国开展的以社区为基础的前瞻性队列研究。从2008年到2010年，共纳入了2088名年龄在40-75岁之间的无糖尿病参与者。在随访访视期间确定了2型糖尿病事件。采用高效液相色谱-在线电喷雾串联质谱法测定基线血清TMAO。使用考克斯比例风险模型计算血清TMAO三分位数间糖尿病的风险比（HR）和95%置信区间（95% CI）。使用线性混合效应模型（LMEMs）估计血清TMAO与血糖特征（空腹血糖、HbA 1c、胰岛素、HOMA-IR）随时间变化的前瞻性相关性。我们在中位随访8.9年期间确定了254例2型糖尿病病例。血清TMAO中位数（四分位距）为1.54（0.86-2.91）μmol/L。从血清TMAO的第一到第三个三分位数，糖尿病的多变量校正HR分别为1.00（参考）、1.17（95% CI：0.84-1.61）和1.42（95% CI：1.03-1.96）（P趋势= 0.031）。LMEMs显示，与最低三分位数相比，最高三分位数血清TMAO中空腹血糖的估计年变化为0.011（0.001-0.022）mmol/L/y（P-相互作用= 0.044）。血清TMAO与HbA 1c、胰岛素和HOMA-IR的纵向变化无关。我们的研究结果表明，在中国中老年人中，血清TMAO升高与2型糖尿病的风险升高和空腹血糖升高相关。试验注册号：NCT 03179657。https://clinicaltrials.gov/ct2/show/NCT03179657? term= NCT 03179657&draw =2&rank=1在线版本包含补充材料，可通过10.1186/s12967-022-03581-7获得。
The role of trimethylamine-N-oxide (TMAO) in the development of diabetes remains controversial, and prospective data are few. We aimed to investigate the association between serum TMAO and incident type 2 diabetes in middle-aged and older adults. This study was based on the Guangzhou Nutrition and Health Study (GNHS), a community-based prospective cohort study in China. A total of 2088 diabetes-free participants aged 40–75 years were included from 2008 to 2010. Incident type 2 diabetes was ascertained during follow-up visits. Baseline serum TMAO was measured by high-performance liquid chromatography with online electrospray ionization tandem mass spectrometry. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for diabetes across tertiles of serum TMAO were calculated using Cox proportional hazard models. Prospective associations of serum TMAO with changes in glycemic traits (fasting glucose, HbA1c, insulin, HOMA-IR) over time were estimated using linear mixed-effects models (LMEMs). We ascertained 254 incident type 2 diabetes cases during a median follow-up of 8.9 years. The median (interquartile range) of serum TMAO was 1.54 (0.86–2.91) μmol/L. From the first to the third tertile of serum TMAO, the multivariable-adjusted HRs for diabetes were 1.00 (reference), 1.17 (95% CI: 0.84–1.61), and 1.42 (95% CI: 1.03–1.96) (P-trend = 0.031). LMEMs showed that the estimated yearly change in fasting glucose was 0.011 (0.001–0.022) mmol/L/y in the highest tertile of serum TMAO, compared with the lowest tertile (P-interaction = 0.044). Serum TMAO was not associated with longitudinal changes in HbA1c, insulin or HOMA-IR. Our findings suggested that higher serum TMAO was associated with a higher risk of type 2 diabetes and an increase in fasting glucose among middle-aged and older Chinese adults. Trial registration: NCT03179657. https://clinicaltrials.gov/ct2/show/NCT03179657?term=NCT03179657&draw=2&rank=1 The online version contains supplementary material available at 10.1186/s12967-022-03581-7.
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影响因子：
5.8
作者：
Fiore, Daniela;Gianfrilli, Daniele;Isidori, Andrea M.
通讯作者：
Isidori, Andrea M.
影响因子：
7.1
作者：
Papandreou, Christopher;Bullo, Monica;Salas-Salvado, Jordi
通讯作者：
Salas-Salvado, Jordi
DOI：
10.1053/j.ajkd.2013.12.006
发表时间：
2014-05
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Levey AS;Inker LA;Coresh J
通讯作者：
Coresh J
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
4.6
作者：
Gruppen EG;Garcia E;Connelly MA;Jeyarajah EJ;Otvos JD;Bakker SJL;Dullaart RPF
通讯作者：
Dullaart RPF