Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps.
Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps.
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DOI：
10.1002/advs.202205105
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发表时间：
2023-03
期刊：
影响因子：
15.1
通讯作者：
Jewell, Christopher M.
中科院分区：
文献类型：
--
作者：
Carey, Sean T.;Bridgeman, Christopher;Jewell, Christopher M.
Autoimmunity and allergies affect a large number of people across the globe. Current approaches to these diseases target cell types and pathways that drive disease, but these approaches are not cures and cannot differentiate between healthy cells and disease‐causing cells. New immunotherapies that induce potent and selective antigen‐specific tolerance is a transformative goal of emerging treatments for autoimmunity and serious allergies. These approaches offer the potential of halting—or even reversing—disease, without immunosuppressive side effects. However, translating successful induction of tolerance to patients is unsuccessful. Biomaterials offer strategies to direct and maximize immunological mechanisms of tolerance through unique capabilities such as codelivery of small molecules or signaling molecules, controlling signal density in key immune tissues, and targeting. While a growing body of work in this area demonstrates success in preclinical animal models, these therapies are only recently being evaluated in human trials. This review will highlight the most recent advances in the use of materials to achieve antigen‐specific tolerance and provide commentary on the current state of the clinical development of these technologies. Immunotherapies that induce antigen‐specific tolerance are a transformative goal of emerging treatments for autoimmunity and allergies. Such approaches can halt or reverse disease without immunosuppressive side effects. Biomaterials offer capabilities to drive potent and selective tolerance, including codelivery of small molecules or biologics, immune tissue targeting, and intrinsic immune modulatory profiles conferred by defined materials property and signal display densities.
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影响因子：
7.3
作者：
Brusko MA;Stewart JM;Posgai AL;Wasserfall CH;Atkinson MA;Brusko TM;Keselowsky BG
通讯作者：
Keselowsky BG
DOI：
10.1007/978-1-4939-8546-3_2
发表时间：
2018-01-01
期刊：
HLA TYPING: METHODS AND PROTOCOLS
影响因子：
--
作者：
Bodis, Gergely;Toth, Victoria;Schwarting, Andreas
通讯作者：
Schwarting, Andreas
影响因子：
64.8
作者：
Clemente-Casares, Xavier;Blanco, Jesus;Santamaria, Pere
通讯作者：
Santamaria, Pere
影响因子：
4.2
作者：
Baldo BA
通讯作者：
Baldo BA
影响因子：
14
作者：
Cho JJ;Stewart JM;Drashansky TT;Brusko MA;Zuniga AN;Lorentsen KJ;Keselowsky BG;Avram D
通讯作者：
Avram D