Cell Cycle Regulation of Stem Cells by MicroRNAs.
Cell Cycle Regulation of Stem Cells by MicroRNAs.
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DOI：
10.1007/s12015-018-9808-y
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发表时间：
2018-06
影响因子：
4.8
通讯作者：
Ghanbari M
中科院分区：
文献类型：
--
作者：
Mens MMJ;Ghanbari M
microRNA（miRNAs）是一类参与基因表达调控的非编码小RNA分子。它们参与许多细胞类型中基本生物过程的微调，例如增殖、分化、存活和凋亡。新出现的证据表明，miRNAs调节干细胞功能的关键途径。已经提出几种miRNA靶向直接或间接协调干细胞的细胞周期进程的转录物。此外，先前的研究已经表明，由于细胞周期调控的丧失，miRNA的表达水平的改变可能导致病理状况，例如癌症。然而，miRNA介导的干细胞细胞周期调控的确切机制仍不完全清楚。本文就miRNAs在干细胞细胞周期进程中的调控作用作一综述。我们描述了特定的miRNA如何控制胚胎、体细胞和癌症干细胞中的细胞周期相关分子和检查点。我们进一步概述了这些miRNAs如何被调节以影响干细胞的细胞周期进程，作为潜在的临床应用。
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the regulation of gene expression. They are involved in the fine-tuning of fundamental biological processes such as proliferation, differentiation, survival and apoptosis in many cell types. Emerging evidence suggests that miRNAs regulate critical pathways involved in stem cell function. Several miRNAs have been suggested to target transcripts that directly or indirectly coordinate the cell cycle progression of stem cells. Moreover, previous studies have shown that altered expression levels of miRNAs can contribute to pathological conditions, such as cancer, due to the loss of cell cycle regulation. However, the precise mechanism underlying miRNA-mediated regulation of cell cycle in stem cells is still incompletely understood. In this review, we discuss current knowledge of miRNAs regulatory role in cell cycle progression of stem cells. We describe how specific miRNAs may control cell cycle associated molecules and checkpoints in embryonic, somatic and cancer stem cells. We further outline how these miRNAs could be regulated to influence cell cycle progression in stem cells as a potential clinical application.
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影响因子：
3.2
作者：
Bao B;Li Y;Ahmad A;Azmi AS;Bao G;Ali S;Banerjee S;Kong D;Sarkar FH
通讯作者：
Sarkar FH
DOI：
10.1083/jcb.201404001
发表时间：
2014-11-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ahmed MI;Alam M;Emelianov VU;Poterlowicz K;Patel A;Sharov AA;Mardaryev AN;Botchkareva NV
通讯作者：
Botchkareva NV
影响因子：
8
作者：
Bhattacharya, A.;Schmitz, U.;Kunz, M.
通讯作者：
Kunz, M.
DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
5.6
作者：
Becker, Klaus A.;Ghule, Prachi N.;Stein, Gary S.
通讯作者：
Stein, Gary S.