Targeting CSC-related miRNAs for cancer therapy by natural agents.
Targeting CSC-related miRNAs for cancer therapy by natural agents.
复制标题
DOI：
10.2174/138945012804545515
复制
发表时间：
2012-12
影响因子：
3.2
通讯作者：
Sarkar FH
中科院分区：
文献类型：
--
作者：
Bao B;Li Y;Ahmad A;Azmi AS;Bao G;Ali S;Banerjee S;Kong D;Sarkar FH
癌症干细胞（CSCs）理论为基本的临床意义提供了证据，因为CSCs参与细胞迁移、侵袭、转移和治疗抵抗，从而导致癌症患者临床结果不佳。因此，靶向CSC将为肿瘤的治疗和/或预防提供新的治疗策略。然而，肿瘤干细胞在肿瘤发生过程中的调控及其信号通路尚不清楚。 MicroRNA (miRNA) 已被证明是基因转录后调控的关键调节因子，参与包括肿瘤发生在内的多种生物过程。 miRNA 表达的改变与被诊断患有多种肿瘤的患者的不良临床结果相关。因此，新出现的证据强烈表明 miRMA 在肿瘤的发生和进展中发挥着关键作用。新的证据还表明，miRNA 参与肿瘤细胞生长、迁移、侵袭、血管生成、耐药性和转移的调节。此外，已经发现 miRNA（例如 let-7、miR-21、miR-22、miR-34、miR-101、miR-146a 和 miR-200）与通过靶向致癌信号通路介导的 CSC 表型和功能相关。在本文中，我们将讨论 miRNA 在肿瘤发生和进展过程中调节 CSC 表型和功能的作用。我们还将讨论天然药物（营养保健品）作为有效抗肿瘤药物的潜在作用，据信这些药物通过靶向 CSC 相关 miRNA 发挥作用。
The theory of cancer stem cells (CSCs) has provided evidence on fundamental clinical implications because of the involvement of CSCs in cell migration, invasion, metastasis, and treatment resistance, which leads to the poor clinical outcome of cancer patients. Therefore, targeting CSCs will provide a novel therapeutic strategy for the treatment and/or prevention of tumors. However, the regulation of CSCs and its signaling pathways during tumorigenesis are not well understood. MicroRNAs (miRNAs) have been proved to act as key regulators of the post-transcriptional regulation of genes, which involve in a wide array of biological processes including tumorigenesis. The altered expressions of miRNAs are associated with poor clinical outcome of patients diagnosed with a variety of tumors. Therefore, emerging evidence strongly suggest that miRMAs play critical roles in tumor development and progression. Emerging evidence also suggest that miRNAs participate in the regulation of tumor cell growth, migration, invasion, angiogenesis, drug resistance, and metastasis. Moreover, miRNAs such as let-7, miR-21, miR-22, miR-34, miR-101, miR-146a, and miR-200 have been found to be associated with CSC phenotype and function mediated through targeting oncogenic signaling pathways. In this article, we will discuss the role of miRNAs in the regulation of CSC phenotype and function during tumor development and progression. We will also discuss the potential role of naturally occurring agents (nutraceuticals) as potent anti-tumor agents that are believed to function by targeting CSC-related miRNAs.
登录
查看更多内容
影响因子：
9
作者：
通讯作者：
--
影响因子：
4
作者：
Bao, Bin;Wang, Zhiwei;Ali, Shadan;Kong, Dejuan;Banerjee, Sanjeev;Ahmad, Aamir;Li, Yiwei;Azmi, Asfar S.;Miele, Lucio;Sarkar, Fazlul H.
通讯作者：
Sarkar, Fazlul H.
影响因子：
3.8
作者：
Ahn, Jiyoung;Albanes, Demetrius;Hayes, Richard B.
通讯作者：
Hayes, Richard B.
DOI：
10.1158/1940-6207.capr-11-0299
发表时间：
2012-03
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Bao B;Wang Z;Ali S;Ahmad A;Azmi AS;Sarkar SH;Banerjee S;Kong D;Li Y;Thakur S;Sarkar FH
通讯作者：
Sarkar FH
影响因子：
6.1
作者：
Bose, Mousumi;Hao, Xingpei;Yang, Chung S.
通讯作者：
Yang, Chung S.