Physiological aspects of exocytosis in chromaffin cells of the adrenal medulla.
Physiological aspects of exocytosis in chromaffin cells of the adrenal medulla.
复制标题
肾上腺髓质嗜铬细胞胞吐作用的生理学方面。
DOI：
10.1046/j.1365-201x.1999.00580.x
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
K. Langley
中科院分区：
文献类型：
--
作者：
D. Aunis;K. Langley
肾上腺髓质主要由肾上腺素能和去甲肾上腺素能嗜铬细胞群组成，还有少量小的强荧光细胞和神经节神经元。不同的分子刺激会在腺体中引起不同的分泌事件，包括肾上腺素或去甲肾上腺素以及各种神经活性肽的释放。分泌反应的性质可以在中央水平控制或在腺体内局部调节。不同类型嗜铬细胞的特定神经支配模式与中枢调节机制有关，同时也提出了几种局部调节分泌的解释。细胞表型之间各种类型受体的差异分布，例如两个主要嗜铬细胞群之间的毒蕈碱或烟碱乙酰胆碱受体、组胺受体、血管紧张素受体和不同类别的阿片受体，可能参与局部控制。此外，胞吐作用参数可以通过表型特异性机制在肾上腺素能和去甲肾上腺素能细胞中进行不同的调节，可能涉及生长相关蛋白 43、突触体相关蛋白 25 亚型或 p11 膜联蛋白亚基等分子。还已知各种类型的钙通道的分布在嗜铬细胞亚型之间有所不同。这篇简短的综述探讨了肾上腺特定神经支配模式的可能编程方式，并讨论了嗜铬细胞表型之间可能存在差异的胞吐机制。这里回顾的数据表明，肾上腺髓质不应再被视为同质实体，而是由单个细胞亚群的集合组成，每个细胞亚群具有独特的分泌反应，可以部分反映其局部历史。
The adrenal medulla is composed principally of groups of adrenergic and noradrenergic chromaffin cells, with minor populations of small intensely fluorescent cells and ganglionic neurones. Different molecular stimuli evoke distinct secretory events in the gland, involving the release of either adrenaline or noradrenaline together with various neuroactive peptides. The nature of the secretory response can be controlled at a central level or regulated locally within the gland. Specific innervation patterns to the different types of chromaffin cell have been implicated in central regulatory mechanisms, while several explanations for regulating secretion locally have been proposed. The differential distribution of various types of receptors between cell phenotypes, such as muscarinic or nicotinic acetylcholine receptors, histamine receptors, angiotensin receptors and different classes of opiate receptors between the two principal chromaffin cell populations could be involved in local control. In addition exocytosis parameters could be modulated differently in adrenergic and noradrenergic cells by phenotype-specific mechanisms, possibly involving molecules like Growth Associated Protein-43, Synaptosomal Associated Protein-25 isoforms or the p11 annexin subunit. The distribution of the various types of calcium channels is also known to vary between chromaffin cell subtypes. This short review examines possible ways in which specific innervation patterns in the adrenal gland could be programmed and discusses exocytosis mechanisms that could differ between chromaffin cell phenotypes. Data reviewed here suggest that the adrenal medulla should no longer be viewed as a homogeneous entity but as consisting of an ensemble of individual cell subpopulations each with a distinct secretory response that could in part reflect its local history.
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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