Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.
Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.
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DOI：
10.1016/j.neuropharm.2017.12.006
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发表时间：
2018-03-15
影响因子：
4.7
通讯作者：
Vendruscolo LF
中科院分区：
文献类型：
--
作者：
Tunstall BJ;Ho CP;Cao J;Vendruscolo JCM;Schmeichel BE;Slack RD;Tanda G;Gadiano AJ;Rais R;Slusher BS;Koob GF;Newman AH;Vendruscolo LF
Methamphetamine (METH) is a highly addictive drug, but no pharmacological treatment is yet available for METH use disorders. Similar to METH, the wake-promoting drug (R)- modafinil (R-MOD) binds to the dopamine transporter (DAT). Unlike METH, R-MOD is not a substrate for transport by DAT and has low abuse potential. We tested the hypothesis that the atypical DAT inhibitor R-MOD and compounds that are derived from Modafinil would decrease METH intake by reducing the actions of METH at the DAT. We tested the effects of systemic injections of R-MOD and four novel Modafinil-derived ligands with increased DAT affinity (JJC8-016, JJC8-088, JJC8-089, and JJC8-091) on intravenous (i.v.) METH self-administration in rats that were allowed short access (ShA; 1 h) or long access (LgA; 6 h) to the drug. ShA rats exhibited stable METH intake over sessions, whereas LgA rats exhibited an escalation of drug intake. R-MOD decreased METH self-administration in ShA and LgA rats (in the 1st hour only). JJC8-091, and JJC8-016 decreased METH self-administration in both ShA and LgA rats. JJC8- 089 decreased METH self-administration in LgA rats only, whereas JJC8-088 had no effect on METH self-administration in either ShA or LgA rats. These findings support the potential of atypical DAT inhibitors for the treatment of METH use disorders and suggest several novel compounds as candidate drugs.
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DOI：
10.1017/s1461145711000988
发表时间：
2012-08
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Reichel CM;See RE
通讯作者：
See RE
影响因子：
4.2
作者：
Reith, Maarten E. A.;Blough, Bruce E.;Hong, Weimin C.;Jones, Kymry T.;Schmitt, Kyle C.;Baumann, Michael H.;Partilla, John S.;Rothman, Richard B.;Katz, Jonathan L.
通讯作者：
Katz, Jonathan L.
DOI：
10.1124/jpet.113.208264
发表时间：
2014-01-01
影响因子：
3.5
作者：
Hiranita, Takato;Kohut, Stephen J.;Katz, Jonathan L.
通讯作者：
Katz, Jonathan L.
影响因子：
7.3
作者：
Okunola-Bakare OM;Cao J;Kopajtic T;Katz JL;Loland CJ;Shi L;Newman AH
通讯作者：
Newman AH
影响因子：
3.4
作者：
Jang, Choon-Gon;Whitfield, Timothy;Schulteis, Gery;Koob, George F.;Wee, Sunmee
通讯作者：
Wee, Sunmee