A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats.
A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats.
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DOI：
10.1007/s00213-012-2864-0
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发表时间：
2013-02
影响因子：
3.4
通讯作者：
Wee, Sunmee
中科院分区：
文献类型：
--
作者：
Jang, Choon-Gon;Whitfield, Timothy;Schulteis, Gery;Koob, George F.;Wee, Sunmee
戒毒过程中的消极情绪状态可能会导致人类的强迫性药物摄入和寻求。研究表明，长期接触甲基苯丙胺会导致大鼠的强迫性药物摄入。本研究验证了这一假说，即延长通路的大鼠的强迫性甲基苯丙胺摄入与戒毒期间的负面情绪状态有关。短时间(1h，Sa)和长时间(6h，LGA)甲基苯丙胺(0.05 mg/kg/次静脉注射)大鼠采用颅内自我刺激(ICSS)进行奖赏阈值测试。不同组的SHA和LGA大鼠在新颖性抑制进食、开阔场地、防御性掩埋和强迫游泳测试中被检测抑郁和焦虑状态。随着接触时间的延长，ICSS阈值逐渐升高，并与药物摄入量的增加呈正相关。在戒毒期间，提高的ICSS阈值恢复到长期接触甲基苯丙胺之前的水平。在再次接触长期接触甲基苯丙胺后，ICSS阈值比最初接触时上升得更快。与沙鼠相比，LGA大鼠在新视野中心接近食物的潜伏期更长，在强迫游泳测试中保持不动的时间也更长。相反，在防御掩埋实验中，SHA大鼠主动掩埋一个厌恶的电击探头，而LGA大鼠则保持不动。数据表明，在大鼠戒断早期，长期接触甲基苯丙胺会产生更多类似抑郁的状态，而不是类似焦虑的状态。
Negative emotional states during drug withdrawal may contribute to compulsive drug intake and seeking in humans. Studies suggest that extended access to methamphetamine induces compulsive drug intake in rats. The present study tested the hypothesis that compulsive methamphetamine intake in rats with extended access is associated with negative emotional states during drug withdrawal. Rats with short (1 h, ShA) and extended access (6 h, LgA) to methamphetamine self-administration (0.05 mg/kg/infusion) were tested for reward thresholds using intracranial self-stimulation (ICSS). Different groups of ShA and LgA rats were examined for depression-like and anxiety-like states in the novelty-suppressed feeding, open field, defensive burying, and forced swim tests. With extended access, ICSS thresholds gradually increased, which was correlated with the increase of drug intake. During drug withdrawal, the increased ICSS thresholds returned to levels observed before exposure to extended access to methamphetamine. Upon re-exposure to extended access to methamphetamine, ICSS thresholds showed a more rapid escalation than during the initial exposure. LgA rats showed a longer latency to approach chow in the center of a novel field and remained immobile longer in the forced swim test than ShA rats did during early withdrawal. In contrast, ShA rats actively buried an aversive shock probe whereas LgA rats remained immobile in the defensive burying test. The data suggest that extended access to methamphetamine produces a more depressive-like state than anxiety-like state in rats during early withdrawal.
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影响因子：
3.4
作者：
Kitamura, O;Wee, S;Pulvirenti, L
通讯作者：
Pulvirenti, L
影响因子：
2.9
作者：
Mantsch, John R.;Cullinan, William E.;Ziegler, Dana R.
通讯作者：
Ziegler, Dana R.
影响因子：
3.6
作者：
BRITTON, DR;BRITTON, KT
通讯作者：
BRITTON, KT
影响因子：
25
作者：
Ahmed, SH;Kenny, PJ;Markou, A
通讯作者：
Markou, A
DOI：
10.1186/1471-2210-11-6
发表时间：
2011-07-18
期刊：
BMC Pharmacology
影响因子：
--
作者：
Hayase, Tamaki
通讯作者：
Hayase, Tamaki