Sex differences in neurodevelopmental trajectories in children with different levels of autistic traits
Sex differences in neurodevelopmental trajectories in children with different levels of autistic traits
复制标题
不同程度自闭症特征儿童神经发育轨迹的性别差异
DOI：
10.1111/pcn.13529
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发表时间：
2023
影响因子：
11.9
通讯作者：
Tsuchiya Kenji J.
中科院分区：
文献类型：
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作者：
Nishimura Tomoko;Takahashi Nagahide;Okumura Akemi;Harada Taeko;Iwabuchi Toshiki;Nakayasu Chikako;Rahman Mohammad Shafiur;Uchiyama Satoshi;Wakuta Manabu;Nomura Yoko;Takei Nori;Senju Atsushi;Tsuchiya Kenji J.
AimLittle对女性自闭症谱系障碍（ASD）的早期表现知之甚少，包括那些可能被当前诊断标准忽视的女性。我们纵向探讨了不同层次的自闭症traits.MethodsThe参与者的儿童的认知和运动功能和适应行为的轨迹的性别差异是824名儿童从滨松出生队列的母亲和儿童（HBC研究），日本，谁被分为三个自闭症特质组低，中，高的社会反应量表第二版的基础上。使用马伦早期学习量表在0.5至3.5岁的7个时间点测量认知和运动功能。在2.7至9岁的五个时间点使用Vineland适应行为量表-第二版测量适应行为。轨迹被描绘使用潜在的增长曲线modeling.ResultsSex-特异性的轨迹中观察到的高-自闭症-特质组，只有男性表现出暂时的下降，在表达语言的年龄约为2年，此后略有改善。他们在适应行为沟通领域也表现出了3年左右的轻微改善，但后来逐渐下降的趋势。女性在高孤独症特质组没有表现出明显的表现在3岁之前，但在3.5年后的适应行为communication domain.Conclusionfemales和男性具有较高的孤独症特质比他们的同性同龄人，独立的临床诊断，可能有不同的表型在某些神经发育领域在婴儿期和幼儿期。
AimLittle is known about early manifestations of autism spectrum disorders (ASD) in females, including those who may be overlooked by the current diagnostic criteria. We longitudinally explored sex differences in the trajectories of cognitive and motor functions and adaptive behaviors in children with different levels of autistic traits.MethodsThe participants were 824 children from the Hamamatsu Birth Cohort for Mothers and Children (HBC Study), Japan, who were classified into three autistic trait groups—low, moderate, and high—based on the Social Responsiveness Scale–Second Edition. Cognitive and motor functions were measured at seven time‐points from 0.5 to 3.5 years of age using the Mullen Scales of Early Learning. Adaptive behaviors were measured at five time‐points from 2.7 to 9 years of age using the Vineland Adaptive Behavior Scales–Second Edition. Trajectories were depicted using latent growth curve modeling.ResultsSex‐specific trajectories were observed in the high‐autistic‐trait group, with only males showing a temporary decline in expressive language around the age of 2 years and a slight improvement thereafter. They also showed a slight improvement around 3 years in the adaptive behavior communication domain but a gradual downward trend later. Females in the high‐autistic‐trait group showed no distinct manifestation before the age of 3 years but showed a downward trend after 3.5 years in the adaptive behavior communication domain.ConclusionFemales and males with higher autistic traits than their same‐sex peers, independent of clinical diagnosis, may have different phenotypes in certain neurodevelopmental domains during infancy and early childhood.
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影响因子：
7.7
作者：
Textor, Johannes;van der Zander, Benito;Ellison, George T. H.
通讯作者：
Ellison, George T. H.
[尚未确诊的患有自闭症谱系障碍的儿童和成人的精神问题]。
DOI：
--
发表时间：
2013
期刊：
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
影响因子：
--
作者：
Y. Kamio;A. Moriwaki;Reiko Takei;N. Inada;Eiko Inokuchi;Hidetoshi Takahashi;T. Nakahachi
通讯作者：
T. Nakahachi
研究综述：对自闭症和非自闭症儿童和青少年社交互动和沟通方面的性别差异进行系统回顾和荟萃分析。
DOI：
--
发表时间：
2020
期刊：
Journal of Child Psychology and Psychiatry and Allied Disciplines
影响因子：
--
作者：
Henry Wood;Bonnie Wong;H. Kovshoff;S. Cortese;J. Hadwin
通讯作者：
J. Hadwin
影响因子：
3.9
作者：
Duvall, Susanne W.;Huang-Storms, Lark;Fombonne, Eric
通讯作者：
Fombonne, Eric
影响因子：
--
作者：
Constantino, JN;Todd, RD
通讯作者：
Todd, RD