PD-1 modulates regulatory T cells and suppresses T-cell responses in HCV-associated lymphoma.
PD-1 modulates regulatory T cells and suppresses T-cell responses in HCV-associated lymphoma.
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DOI：
10.1038/icb.2010.121
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发表时间：
2011-05
影响因子：
4
通讯作者：
Yao, Zhi Q.
中科院分区：
文献类型：
--
作者：
Ni, Lei;Ma, Cheng J.;Zhang, Ying;Nandakumar, Subhadra;Zhang, Chun L.;Wu, Xiao Y.;Borthwick, Thomas;Hamati, Agnes;Chen, Xin Y.;Kumaraguru, Uday;Moorman, Jonathan P.;Yao, Zhi Q.
T调节（TR）细胞抑制T细胞反应，这是关键的慢性病毒感染和相关的恶性肿瘤的发展。程序性死亡-1（PD-1）也在慢性病毒感染期间调节T细胞功能中发挥关键作用。为了检查PD-1途径在调节TR细胞功能中的作用，所述TR细胞功能在病毒相关恶性肿瘤期间抑制T细胞应答，在丙型肝炎病毒相关淋巴瘤（HCV-L）、非HCV相关淋巴瘤（非HCV-L）、单独HCV感染和健康受试者（HS）的背景下研究TR细胞。与来自非HCV-L或单独HCV或HS的受试者相比，在HCV-L受试者的外周血中发现相对高数量的CD 4 + CD 25+和CD 8 + CD 25 + TR细胞以及这些TR细胞上的高水平PD-1表达。来自HCV-L受试者的TR细胞能够抑制自体淋巴细胞应答，并且来自HCV-L的PBMC中的TR细胞的消耗改善了T细胞增殖。此外，HCV-L中受抑制的T细胞活化和增殖通过离体阻断PD-1途径部分恢复，导致TR细胞数量减少和TR抑制效应T细胞活性的能力降低。这项研究表明，PD-1通路参与调节TR细胞，在HCV相关B细胞淋巴瘤的背景下抑制T细胞功能。
T regulatory (TR) cells suppress T cell responses that are critical in the development of chronic viral infection and associated malignancies. Programmed death-1 (PD-1) also plays a pivotal role in regulation of T cell functions during chronic viral infection. To examine the role of PD-1 pathway in regulating TR cell functions that inhibit T cell responses during virus-associated malignancy, TR cells were investigated in the setting of hepatitis C virus-associated lymphoma (HCV-L), non-HCV-associated lymphoma (non-HCV-L), HCV infection alone, and healthy subjects (HS). Relatively high numbers of CD4+CD25+ and CD8+CD25+ TR cells as well as high levels of PD-1 expressions on these TR cells were found in the peripheral blood of subjects with HCV-L compared to those from non-HCV-L or HCV alone or HS. TR cells from the HCV-L subjects were capable of suppressing the autogeneic lymphocyte response, and depletion of TR cells in PBMC from HCV-L improved T cell proliferation. Additionally, the suppressed T cell activation and proliferation in HCV-L was partially restored by blocking the PD-1 pathway ex vivo, resulting in both a reduction in TR cell number and the ability of TR to suppress the activity of effector T cells. This study suggests that the PD-1 pathway is involved in regulating TR cells that suppress T cell functions in the setting of HCV-associated B cell lymphoma.
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影响因子：
25.7
作者：
Lechmann, M;Woitas, RP;Spengler, U
通讯作者：
Spengler, U
影响因子：
15.9
作者：
Rehermann, B;Chang, KM;Chisari, FV
通讯作者：
Chisari, FV
影响因子：
2.2
作者：
Yao, Zhi Q.;King, Ellis;Moorman, Jonathan
通讯作者：
Moorman, Jonathan
影响因子：
6.4
作者：
Yao, Zhi Qiang;Prayther, Deborah;Moorman, Jonathan
通讯作者：
Moorman, Jonathan
影响因子：
15.9
作者：
Chang, KM;Rehermann, B;Chisari, FV
通讯作者：
Chisari, FV