Vagus nerve stimulation during rehabilitative training enhances recovery of forelimb function after ischemic stroke in aged rats.
Vagus nerve stimulation during rehabilitative training enhances recovery of forelimb function after ischemic stroke in aged rats.
复制标题
DOI：
10.1016/j.neurobiolaging.2016.03.030
复制
发表时间：
2016-07
影响因子：
4.2
通讯作者：
Kilgard MP
中科院分区：
文献类型：
--
作者：
Hays SA;Ruiz A;Bethea T;Khodaparast N;Carmel JB;Rennaker RL 2nd;Kilgard MP
高龄与较高的中风发生率和较差的功能预后相关。迷走神经刺激（VNS）与康复训练相结合已成为一种改善脑损伤后恢复的潜在方法，但迄今为止仅在年轻大鼠中进行了评估。在此，我们评估了VNS与康复训练相结合是否能改善18月龄大鼠运动皮质缺血性损伤后前肢功能的恢复。大鼠被训练去执行等长拉力任务，这是一种自动的、定量的测量意志前肢力量的方法。一旦熟练，大鼠接受运动皮质缺血损伤，并进行为期6周的VNS康复训练。VNS配合康复训练可显著促进损伤后前肢功能的恢复。无VNS的康复训练可使前肢功能恢复34%±19%，而VNS配合康复训练可使前肢功能恢复98%±8%。VNS不能显著减小病变大小。这些发现表明，在脑卒中模型中，VNS与康复训练相结合可以增强老年受试者的运动恢复，并可能表明VNS疗法可以有效地转化为老年脑卒中患者。
Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength. Once proficient, rats received an ischemic lesion of the motor cortex and underwent rehabilitative training paired with VNS for 6 weeks. VNS paired with rehabilitative training significantly enhances recovery of forelimb function after lesion. Rehabilitative training without VNS results in a 34% ± 19% recovery, whereas VNS paired with rehabilitative training yields a 98% ± 8% recovery of prelesion of forelimb function. VNS does not significantly reduce lesion size. These findings demonstrate that VNS paired with rehabilitative training enhances motor recovery in aged subjects in a model of stroke and may suggest that VNS therapy may effectively translate to elderly stroke patients.
登录
查看更多内容
影响因子：
3.7
作者：
Furmaga H;Carreno FR;Frazer A
通讯作者：
Frazer A
影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
DOI：
10.1016/s1052-3057(03)00042-9
发表时间：
2003-05-01
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
--
作者：
Kelly-Hayes, Margaret;Beiser, Alexa;Wolf, Philip A
通讯作者：
Wolf, Philip A
影响因子：
2.5
作者：
Foley, JO;DuBois, F
通讯作者：
DuBois, F
影响因子：
16.2
作者：
Conner, JM;Chiba, AA;Tuszynski, MH
通讯作者：
Tuszynski, MH