Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer's disease.
Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer's disease.
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DOI：
10.1093/braincomms/fcab003
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发表时间：
2021
影响因子：
4.8
通讯作者：
Crutch SJ
中科院分区：
文献类型：
--
作者：
Lu K;Nicholas JM;Weston PSJ;Stout JC;O'Regan AM;James SN;Buchanan SM;Lane CA;Parker TD;Keuss SE;Keshavan A;Murray-Smith H;Cash DM;Sudre CH;Malone IB;Coath W;Wong A;Richards M;Henley SMD;Fox NC;Schott JM;Crutch SJ
我们调查了家族性和散发性临床前阿尔茨海默病患者是否存在细微的视觉运动缺陷。31名有50%家族性阿尔茨海默病风险的个体(19名症状前突变携带者，12名非携带者)和390名认知正常的老年人(英国1946年出生队列成员，都出生在同一周；评估的年龄范围=69-71 )完成了一项圆圈追踪任务-包括直接和间接视觉反馈，以及双重任务减法-他们还接受了β-淀粉样蛋白-正电子发射计算机体层摄影/核磁共振成像，得出淀粉样蛋白状态(阳性/阴性)、全脑体积和脑白质高信号体积。我们对临床前阿尔茨海默病患者组和对照组(突变携带者和非携带者；淀粉样蛋白阳性和淀粉样蛋白阴性)在圆圈追踪和减法的速度和准确性方面进行了横截面比较。突变携带者(平均在预期发病前7 年)和淀粉样阳性老年人在视觉反馈是间接的情况下，追踪准确率比对照组低得不成比例，在双重任务减法时速度更慢。在老年人中，当将淀粉样蛋白负荷作为一个连续变量(标准化摄取值比率)时，也发现了同样的关联模式。淀粉样蛋白的作用独立于白质高强度和脑体积，而白质高强度和脑体积本身与表现的不同方面有关：当视觉反馈是间接的时，白质高强度体积也与不成比例地较差的追踪准确性相关，而较大的脑体积与更快的追踪和更快的减法相关。当视觉反馈是直接的时，突变携带者也显示出跟踪准确性较差的证据。这项研究首次提供了家族性和散发性临床前阿尔茨海默病常见的视觉运动整合缺陷的证据，这可能比临床症状出现早几年。使用具有直接和间接视觉反馈的计算机化的圆圈跟踪任务，Lu等人。首次报道了家族性和散发性阿尔茨海默病患者的视觉运动整合缺陷的证据，表明这些缺陷可能比临床症状的出现早了几年。
We investigated whether subtle visuomotor deficits were detectable in familial and sporadic preclinical Alzheimer’s disease. A circle-tracing task—with direct and indirect visual feedback, and dual-task subtraction—was completed by 31 individuals at 50% risk of familial Alzheimer’s disease (19 presymptomatic mutation carriers; 12 non-carriers) and 390 cognitively normal older adults (members of the British 1946 Birth Cohort, all born during the same week; age range at assessment = 69–71 years), who also underwent β-amyloid-PET/MRI to derive amyloid status (positive/negative), whole-brain volume and white matter hyperintensity volume. We compared preclinical Alzheimer’s groups against controls cross-sectionally (mutation carriers versus non-carriers; amyloid-positive versus amyloid-negative) on speed and accuracy of circle-tracing and subtraction. Mutation carriers (mean 7 years before expected onset) and amyloid-positive older adults traced disproportionately less accurately than controls when visual feedback was indirect, and were slower at dual-task subtraction. In the older adults, the same pattern of associations was found when considering amyloid burden as a continuous variable (Standardized Uptake Value Ratio). The effect of amyloid was independent of white matter hyperintensity and brain volumes, which themselves were associated with different aspects of performance: greater white matter hyperintensity volume was also associated with disproportionately poorer tracing accuracy when visual feedback was indirect, whereas larger brain volume was associated with faster tracing and faster subtraction. Mutation carriers also showed evidence of poorer tracing accuracy when visual feedback was direct. This study provides the first evidence of visuomotor integration deficits common to familial and sporadic preclinical Alzheimer’s disease, which may precede the onset of clinical symptoms by several years. Using a computerized circle-tracing task with direct and indirect visual feedback, Lu et al. report the first evidence of visuomotor integration deficits in both familial and sporadic preclinical Alzheimer’s disease groups, suggesting that these deficits might precede the onset of clinical symptoms by several years.
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DOI：
10.1002/dad2.12076
发表时间：
2020-01-01
影响因子：
5.3
作者：
Lu, Kirsty;Nicholas, Jennifer M.;Crutch, Sebastian J.
通讯作者：
Crutch, Sebastian J.
影响因子：
3.4
作者：
Gorbet, Diana J.;Sergio, Lauren E.
通讯作者：
Sergio, Lauren E.
影响因子：
6
作者：
Joshi, Aditi;Ringman, John M.;Mendez, Mario F.
通讯作者：
Mendez, Mario F.
影响因子：
48
作者：
Ryan, Natalie S.;Nicholas, Jennifer M.;Fox, Nick C.
通讯作者：
Fox, Nick C.
DOI：
10.3233/jad-121255
发表时间：
2013
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Scahill RI;Ridgway GR;Bartlett JW;Barnes J;Ryan NS;Mead S;Beck J;Clarkson MJ;Crutch SJ;Schott JM;Ourselin S;Warren JD;Hardy J;Rossor MN;Fox NC
通讯作者：
Fox NC