Position effects on promoter activity in Escherichia coli and their consequences for antibiotic-resistance determinants.
Position effects on promoter activity in Escherichia coli and their consequences for antibiotic-resistance determinants.
复制标题
大肠杆菌启动子活性的位置效应及其对抗生素耐药性决定因素的影响。
DOI:
10.1042/bst20180503
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发表时间:
2019
影响因子:
3.9
通讯作者:
Cooke K
中科院分区:
文献类型:
--
作者:
Cooke K
The activity of any bacterial promoter is generally supposed to be set by its base sequence and the different transcription factors that bind in the local vicinity. Here, we review recent data indicating that the activity of theEscherichia coli lacoperon promoter also depends upon its chromosomal location. Factors that affect promoter activity include the binding of nucleoid-associated proteins to neighbouring sequences, supercoiling and the activity of neighbouring promoters. We suggest that many bacterial promoters might be susceptible to similar position-dependent effects and we review recent data showing that the expression of mobile genes encoding antibiotic-resistance determinants is also location-dependent, both when carried on a bacterial chromosome or a conjugative plasmid.
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DOI:
--
发表时间:
1968
期刊:
Cold Spring Harbor Symposia on Quantitative Biology
影响因子:
--
作者:
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1997
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Plasmid.
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期刊:
G3 (Bethesda, Md.)
影响因子:
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通讯作者:
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影响因子:
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作者:
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通讯作者:
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DOI:
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发表时间:
1968
期刊:
Cold Spring Harbor Symposia on Quantitative Biology
影响因子:
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作者:
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通讯作者:
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