Cancer-type dependent expression of CK2 transcripts.
Cancer-type dependent expression of CK2 transcripts.
复制标题
DOI：
10.1371/journal.pone.0188854
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Dominguez I
中科院分区：
文献类型：
--
作者：
Chua MMJ;Lee M;Dominguez I
许多蛋白质在癌细胞中异常表达，包括致癌丝氨酸-苏氨酸激酶CK 2。在以前的报告中，我们发现CK 2转录表达增加，这可以解释在肺癌和支气管癌、前列腺癌、乳腺癌、结肠癌和直肠癌、卵巢癌和胰腺癌中发现的CK 2蛋白水平增加。我们还发现，与目前关于CK 2的概念相反，一些CK 2转录本在几种癌症中下调。在这里，我们使用Oncomine研究了所有其他癌症，以确定它们是否也显示出显著的CK 2转录失调。正如我们之前的分析所预期的，我们发现所有CK 2转录物上调的癌症（例如宫颈癌），以及CK 2转录物上调和/或下调的组合的癌症（例如肉瘤）。出乎意料的是，我们发现一些癌症的所有CK 2转录物都显著下调（例如睾丸癌）。我们还发现，在某些情况下，CK 2转录水平已经在良性病变（如巴雷特食管）失调。我们还发现，在大多数情况下，CK 2转录上调与患者生存率降低相关，其中数据是显着的。然而，有两种癌症类型，胶质母细胞瘤和肾细胞癌，其中CK 2转录上调与较高的生存率相关。总体而言，这些数据表明，CK 2基因的表达水平在癌症中高度可变，并可能导致不同的患者结局。
A multitude of proteins are aberrantly expressed in cancer cells, including the oncogenic serine-threonine kinase CK2. In a previous report, we found increases in CK2 transcript expression that could explain the increased CK2 protein levels found in tumors from lung and bronchus, prostate, breast, colon and rectum, ovarian and pancreatic cancers. We also found that, contrary to the current notions about CK2, some CK2 transcripts were downregulated in several cancers. Here, we investigate all other cancers using Oncomine to determine whether they also display significant CK2 transcript dysregulation. As anticipated from our previous analysis, we found cancers with all CK2 transcripts upregulated (e.g. cervical), and cancers where there was a combination of upregulation and/or downregulation of the CK2 transcripts (e.g. sarcoma). Unexpectedly, we found some cancers with significant downregulation of all CK2 transcripts (e.g. testicular cancer). We also found that, in some cases, CK2 transcript levels were already dysregulated in benign lesions (e.g. Barrett’s esophagus). We also found that CK2 transcript upregulation correlated with lower patient survival in most cases where data was significant. However, there were two cancer types, glioblastoma and renal cell carcinoma, where CK2 transcript upregulation correlated with higher survival. Overall, these data show that the expression levels of CK2 genes is highly variable in cancers and can lead to different patient outcomes.
登录
查看更多内容
DOI：
10.3390/ph10010018
发表时间：
2017-01-28
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Chua MM;Ortega CE;Sheikh A;Lee M;Abdul-Rassoul H;Hartshorn KL;Dominguez I
通讯作者：
Dominguez I
影响因子：
3.3
作者：
Chen, X;Cheung, ST;Brown, PO
通讯作者：
Brown, PO
影响因子：
64.8
作者：
Alizadeh, AA;Eisen, MB;Staudt, LM
通讯作者：
Staudt, LM
影响因子：
5.3
作者：
Choi, Sung E.;Kwon, Sanghoon;Kemper, Jongsook Kim
通讯作者：
Kemper, Jongsook Kim
影响因子：
64.8
作者：
Compagno, Mara;Lim, Wei Keat;Grunn, Adina;Nandula, Subhadra V.;Brahmachary, Manisha;Shen, Qiong;Bertoni, Francesco;Ponzoni, Maurilio;Scandurra, Marta;Califano, Andrea;Bhagat, Govind;Chadburn, Amy;Dalla-Favera, Riccardo;Pasqualucci, Laura
通讯作者：
Pasqualucci, Laura