Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy.
Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy.
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DOI：
10.1038/srep00906
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发表时间：
2012
影响因子：
4.6
通讯作者：
Rameshwar, Pranela
中科院分区：
文献类型：
--
作者：
Patel, Shyam A.;Ramkissoon, Shakti H.;Bryan, Margarette;Pliner, Lillian F.;Dontu, Gabriela;Patel, Prem S.;Amiri, Sohrab;Pine, Sharon R.;Rameshwar, Pranela
骨髓（BM）是乳腺癌（BC）休眠的主要器官，也是乳腺癌复发的常见来源。BC细胞（bcc）和BM间质之间的间隙连接细胞间通讯（GJIC）有助于休眠。本研究报告了bcc的一个层次结构，其中最不成熟的亚群（Oct4hi/CD44hi/med/CD24−/+）表现出化疗耐药、休眠和干细胞特性：自我更新、连续传代能力、循环静止、长加倍时间、不对称分裂、高转移和侵袭能力。体外和体内研究表明，该亚群与BM基质的GJIC有关。在积极治疗的患者和肿瘤较大但未累及淋巴结的患者的血液中也检测到类似的bcc。简而言之，这些发现确定了一种具有干细胞特性的新型BCC亚群，具有休眠和患者循环的偏好。这些发现建立了基于表型和功能的bcc的工作细胞层次结构。
The bone marrow (BM) is a major organ of breast cancer (BC) dormancy and a common source of BC resurgence. Gap junctional intercellular communication (GJIC) between BC cells (BCCs) and BM stroma facilitates dormancy. This study reports on a hierarchy of BCCs with the most immature subset (Oct4hi/CD44hi/med/CD24−/+) demonstrating chemoresistance, dormancy, and stem cell properties: self-renewal, serial passaging ability, cycling quiescence, long doubling time, asymmetric division, high metastatic and invasive capability. In vitro and in vivo studies indicated that this subset was responsible for GJIC with BM stroma. Similar BCCs were detected in the blood of patients despite aggressive treatment and in a patient with a relatively large tumor but no lymph node involvement. In brief, these findings identified a novel BCC subset with stem cell properties, with preference for dormancy and in the circulation of patients. The findings establish a working cellular hierarchy of BCCs based on phenotype and functions.
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影响因子：
45.3
作者：
Liu, Suling;Wicha, Max S.
通讯作者：
Wicha, Max S.
影响因子：
2.9
作者：
Kim RJ;Nam JS
通讯作者：
Nam JS
DOI：
10.1186/bcr3019
发表时间：
2011-09-27
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Beltran AS;Rivenbark AG;Richardson BT;Yuan X;Quian H;Hunt JP;Zimmerman E;Graves LM;Blancafort P
通讯作者：
Blancafort P
影响因子：
11.2
作者：
Lim, Philip K.;Bliss, Sarah A.;Rameshwar, Pranela
通讯作者：
Rameshwar, Pranela
影响因子：
2.3
作者：
Cirenajwis, Helena;Smiljanic, Sandra;Oredsson, Stina M.
通讯作者：
Oredsson, Stina M.