Lab-on-tip: Protruding-shaped all-fiber plasmonic microtip probe toward in-situ chem-bio detection
Lab-on-tip: Protruding-shaped all-fiber plasmonic microtip probe toward in-situ chem-bio detection
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Lab-on-tip：用于原位化学-生物检测的凸形全纤维等离子体微尖探针
DOI：
10.1016/j.snb.2019.127128
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发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Biao Wang
中科院分区：
文献类型：
--
作者：
Ling-Xin Kong;Yan-Xin Zhang;Wei-Gang Zhang;Yun-Shan Zhang;Tie-Yi Yan;Peng-Cheng Geng;Biao Wang
尖端实验室技术为光纤表面等离子体共振（SPR）传感器打开了一扇新的大门。在本文中，我们首先在实验中展示了一种超紧凑的反射SPR微探针，它的长度为几十微米，直径为几微米。仿真和实验表明，这种包覆纳米金膜的光纤SPR微探针具有优异的折射率（RI）传感特性，在单细胞水平上具有很大的生物化学检测潜力。利用壳聚糖/聚苯乙烯磺酸钠（Cs/PSS）纳米聚电解质膜和羊抗人IgG- hrp组装的生物探针具有较高的RI灵敏度，可特异性识别人IgG。由于SPR微针尖探针具有很高的表面灵敏度，对人IgG具有超低的检测限。针对聚二甲基硅氧烷（PDMS）体灵敏度高、热光学系数（TOC）高的特点，提出了一种基于SPR微针尖的参考温度探针，用于补偿生物探针的温度交叉灵敏度。这种新型SPR微探针不仅可用于光纤传感器，还可用于尖端增强近场拉曼显微镜和扫描近场光学显微镜。
Lab-on-tip technology opens a new door for optical fiber surface plasmon resonance (SPR) sensors. In this paper, we first demonstrate an ultra-compact reflective SPR microtip probe on the flat fiber end in experiment, which has a length of tens of microns and a diameter of several microns. Simulations and experiments show that this new fiber SPR microtip probe coated with a nano-goldfilm has excellent refractive index (RI) sensing characteristic and great potential for biochemical detection at single cell level. Based on the high RI sensitivity, a bio-probe assembled with Chitosan/Polysodium Styrene Sulfonate (Cs/PSS) nano-polyelectrolyte film and the sheep anti-human IgG-HRP is prepared to recognize human IgG specifically. Due to the high surface sensitivity, the SPR microtip probe exhibits an ultra-low detection limit for human IgG. Due to the high bulk sensitivity and high thermo-optical coefficient (TOC) of polydimethylsiloxane (PDMS), a reference temperature probe based on SPR microtip is proposed, which is used to compensate for the temperature cross-sensitivity of the bio-probe. This new SPR microtip probe can be used not only in optical fiber sensor, but also in Tip-Enhanced Near-Field Raman Microscopy and Scanning Near-Field Optical Microscope.
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影响因子：
8.4
作者：
Yang, Qingbo;Wang, Hanzheng;Lan, Xinwei;Cheng, Baokai;Chen, Sisi;Shi, Honglan;Xiao, Hai;Ma, Yinfa
通讯作者：
Ma, Yinfa
影响因子：
4.3
作者：
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影响因子：
10.8
作者：
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通讯作者：
Willner, Itamar
影响因子：
8.4
作者：
N. Paliwal;J. John
通讯作者：
N. Paliwal;J. John
DOI：
10.1109/tim.2015.2434094
发表时间：
2015-11-01
影响因子：
5.6
作者：
Zhao, Yong;Deng, Ze-Qun;Hu, Hai-Feng
通讯作者：
Hu, Hai-Feng