Enteric glia in homeostasis and disease: From fundamental biology to human pathology.

Enteric glia in homeostasis and disease: From fundamental biology to human pathology.
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肠神经胶质细胞在稳态和疾病:从基础生物学到人类病理学。

DOI:
10.1016/j.isci.2021.102863
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发表时间:
2021-08-20
期刊:
影响因子:
5.8
通讯作者:
Rao M
Rao M
中科院分区:
综合性期刊2区
文献类型:
--
作者:
Rosenberg HJ;Rao M

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神经胶质细胞是神经系统中的非神经元细胞,长期以来被认为是次级细胞,仅用于支持其更重要的神经元邻居的功能。在过去的二十年里,许多研究小组的工作已经完全推翻了这一概念,揭示了神经胶质细胞在神经系统发育,可塑性和健康方面的无数重要功能。脑外最大的神经胶质细胞群是在肠神经系统中,肠神经系统是自主神经系统的一个分支,构成肠-脑轴的关键节点。在这里,我们回顾了最新的理解,这些肠道神经胶质细胞在哺乳动物中的重点是它们在人类健康和疾病的推定作用。神经科学;微生物组;胃肠病学
Glia, the non-neuronal cells of the nervous system, were long considered secondary cells only necessary for supporting the functions of their more important neuronal neighbors. Work by many groups over the past two decades has completely overturned this notion, revealing the myriad and vital functions of glia in nervous system development, plasticity, and health. The largest population of glia outside the brain is in the enteric nervous system, a division of the autonomic nervous system that constitutes a key node of the gut-brain axis. Here, we review the latest in the understanding of these enteric glia in mammals with a focus on their putative roles in human health and disease. Neuroscience; Microbiome; Gastroenterology
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发表时间: 2006-01-01
期刊: GUT
影响因子: 24.5
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