Development and Internal Validation of Fatty Liver Prediction Models in Obese Children and Adolescents.
Development and Internal Validation of Fatty Liver Prediction Models in Obese Children and Adolescents.
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DOI：
10.3390/jcm10071470
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发表时间：
2021-04-02
影响因子：
3.9
通讯作者：
Sartorio A
中科院分区：
文献类型：
--
作者：
Bedogni G;Tamini S;Caroli D;Cicolini S;Domenicali M;Sartorio A
为了建立脂肪肝（FL）的预测模型，我们对1672名中位年龄（四分位距）为15（13-16）岁的肥胖儿童进行了一项横断面回顾性研究。结果变量是超声诊断的FL。潜在的预测因素为：（1）二进制：性;（2）连续性：年龄、体重指数（BMI）、腰围（WC）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶、γ-谷氨酰转移酶、葡萄糖、胰岛素、胰岛素抵抗的稳态模型评估（HOMA-IR）、HDL-胆固醇、LDL-胆固醇、甘油三酯、平均动脉压、尿酸和C-反应蛋白;（3）顺序：青春期状态。使用分数多项式的Bootstrapped多变量logistic回归来开发模型。开发了两个模型并进行了内部验证，一个使用BMI，另一个使用WC作为人体测量预测。两种模型均包括ALT、HOMA-IR、甘油三酯和尿酸作为预测因子，具有相似的区分度（c-统计量= 0.81），并且通过校准图确定的校准效果相似。这些模型在用于临床或研究实践之前应经过外部验证。
To develop predictive models of fatty liver (FL), we performed a cross-sectional retrospective study of 1672 obese children with a median (interquartile range) age of 15 (13–16) years. The outcome variable was FL diagnosed by ultrasonography. The potential predictors were: (1) binary: sex; (2) continuous: age, body mass index (BMI), waist circumference (WC), alanine transaminase (ALT), aspartate transaminase, gamma-glutamyltransferase, glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), HDL-cholesterol, LDL-cholesterol, triglycerides, mean arterial pressure, uric acid, and c-reactive protein; (3) ordinal: Pubertal status. Bootstrapped multivariable logistic regression with fractional polynomials was used to develop the models. Two models were developed and internally validated, one using BMI and the other using WC as the anthropometric predictor. Both models included ALT, HOMA-IR, triglycerides, and uric acid as predictors, had similar discrimination (c-statistic = 0.81), and were similarly well calibrated as determined by calibration plots. These models should undergo external validation before being employed in clinical or research practice.
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影响因子：
39.2
作者：
Collins, Gary S.;Reitsma, Johannes B.;Moons, Karel G. M.
通讯作者：
Moons, Karel G. M.
影响因子：
5.9
作者：
Bedogni, Giorgio;Bertoli, Simona;Sartorio, Alessandro
通讯作者：
Sartorio, Alessandro
影响因子：
4.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Vos MB
影响因子：
2.4
作者：
Foschi, Francesco Giuseppe;Bedogni, Giorgio;Stefanini, Giuseppe Francesco
通讯作者：
Stefanini, Giuseppe Francesco