Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.
Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.
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DOI：
10.4049/jimmunol.1400556
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发表时间：
2014-07-15
期刊：
影响因子：
--
通讯作者：
Jabri B
中科院分区：
文献类型：
--
作者：
Orbelyan GA;Tang F;Sally B;Solus J;Meresse B;Ciszewski C;Grenier JC;Barreiro LB;Lanier LL;Jabri B
The NKG2 family of NK receptors includes activating and inhibitory members. With the exception of the homodimer-forming NKG2D, NKG2 receptors recognize the nonclassical MHC class I molecule HLA-E, and can be subdivided into two groups: those that associate with and signal through DAP12 to activate cells and those that contain an ITIM motif to promote inhibition. The function of NKG2 family member NKG2E is unclear in humans and its surface expression has never been conclusively established, largely because there is no antibody that binds specifically to NKG2E. Seeking to determine a role for this molecule, we chose to investigate its expression and ability to form complexes with intracellular signaling molecules. We found that NKG2E was capable of associating with CD94 and DAP12 but that the complex was retained intracellularly at the ER instead of being expressed on cell surfaces, and that this localization was dependent on a sequence of hydrophobic amino acids in the extracellular domain of NKG2E. As this particular sequence has emerged and been conserved selectively among higher order primates evolutionarily, this observation raises the intriguing possibility that NKG2E may function as an intracellular protein.
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DOI：
10.1038/nri3044
发表时间：
2011-08-26
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.4
作者：
Kaiser, BK;Barahmand-pour, F;Strong, RK
通讯作者：
Strong, RK
影响因子：
20.3
作者：
Gumá, M;Angulo, A;López-Botet, M
通讯作者：
López-Botet, M
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
DOI：
10.1073/pnas.95.9.5199
发表时间：
1998-04-28
影响因子：
11.1
作者：
Lee, N;Llano, M;Geraghty, DE
通讯作者：
Geraghty, DE