Therapeutic efficacy of artemether-lumefantrine for Plasmodium vivax infections in a prospective study in Guyana.
Therapeutic efficacy of artemether-lumefantrine for Plasmodium vivax infections in a prospective study in Guyana.
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DOI：
10.1186/1475-2875-11-347
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发表时间：
2012-10-19
期刊：
影响因子：
3
通讯作者：
Picot S
中科院分区：
文献类型：
--
作者：
Eibach D;Ceron N;Krishnalall K;Carter K;Bonnot G;Bienvenu AL;Picot S
在圭亚那，氯喹+伯氨喹用于治疗间日疟疾。间日疟原虫对氯喹的耐药性在世界范围内的增加导致了对当前疟疾治疗指南的质疑。采用蒿甲醚-氨苯曲明+伯氨喹对间日疟原虫进行疗效研究，以评价氯喹的替代治疗方案。2009年至2010年，在圭亚那的两家医院进行了一项非对照研究。共有61例间日疟原虫感染患者接受蒿甲醚-氨苯曲明治疗，共6次，每天2次，连续3天，第0天另加0.25 mg/kg/d的伯氨喹，连续14天。按照世卫组织指南，在第0、1、2、3、7、14和28天监测临床和寄生虫学参数。对8例间日疟原虫耐药分子标记pvmdr1进行DNA分析。第1天蒿甲醚-甲氨芳啶清除了100%的寄生虫，但2例（3%）患者在第28天寄生虫复发，提示复发。未检测到pvmdr1 Y976F多态性。治疗方案耐受性良好。在圭亚那，当与伯氨喹联合使用时，蒿甲醚-氨苯曲明是对抗间日疟的适当治疗选择。在间日疟原虫出现氯喹耐药性的情况下，这种替代品的可用性将非常重要。
In Guyana, chloroquine + primaquine is used for the treatment of vivax malaria. A worldwide increase of chloroquine resistance in Plasmodium vivax led to questioning of the current malaria treatment guidelines. A therapeutic efficacy study was conducted using artemether-lumefantrine + primaquine against P. vivax to evaluate a treatment alternative for chloroquine. From 2009 to 2010, a non-controlled study in two hospitals in Guyana was conducted. A total 61 patients with P. vivax infection were treated with artemether-lumefantrine as a six-dose regimen twice a day for three days with additional 0.25 mg/kg/d primaquine at day 0 for 14 days. Clinical and parasitological parameters were followed on days 0,1,2,3,7,14 and 28 in agreement with WHO guidelines. Plasmodium vivax DNA from eight patients was analysed for pvmdr1, molecular marker of resistance. Artemether-lumefantrine cleared 100% of parasites on day 1, but two patients (3%) had recurrence of parasites on day 28, suggesting relapse. No pvmdr1 Y976F polymorphism was detected. The treatment regimen was well tolerated. In Guyana, artemether-lumefantrine represents an adequate treatment option against P. vivax when combined with primaquine. Availability of this alternative will be of great importance in case of emerging chloroquine resistance against P. vivax.
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DOI：
10.4269/ajtmh.2009.80.194
发表时间：
2009-02-01
影响因子：
3.3
作者：
Kochar, Dhanpat K.;Das, Ashish;Gupta, Vikas
通讯作者：
Gupta, Vikas
影响因子：
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作者：
Phillips, EJ;Keystone, JS;Kain, KC
通讯作者：
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影响因子：
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作者：
Marfurt, Jutta;de Monbrison, Frederique;Genton, Blaise
通讯作者：
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影响因子：
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作者：
Krudsood, Srivicha;Tangpukdee, Noppadon;Looareesuwan, Sornchai
通讯作者：
Looareesuwan, Sornchai
DOI：
10.1590/s0036-46651991000200009
发表时间：
1991-03-01
影响因子：
1.9
作者：
BOULOS, M;NETO, VA;SHIROMA, M
通讯作者：
SHIROMA, M