Association between autozygosity and major depression: stratification due to religious assortment.
Association between autozygosity and major depression: stratification due to religious assortment.
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DOI：
10.1007/s10519-013-9610-1
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发表时间：
2013-11
影响因子：
2.6
通讯作者：
Boomsma, Dorret I.
中科院分区：
文献类型：
--
作者：
Abdellaoui, Abdel;Hottenga, Jouke-Jan;Xiao, Xiangjun;Scheet, Paul;Ehli, Erik A.;Davies, Gareth E.;Hudziak, James J.;Smit, Dirk J. A.;Bartels, Meike;Willemsen, Gonneke;Brooks, Andrew;Sullivan, Patrick F.;Smit, Johannes H.;de Geus, Eco J.;Penninx, Brenda W. J. H.;Boomsma, Dorret I.
关键词：
近亲繁殖对后代健康的影响可以通过测量全基因组自合子（纯合子序列中基因组的比例（Froh））来研究，并将Froh与精神表型等结果联系起来。为了成功地进行这些研究，应该很好地理解和解释群体之间和群体内部全基因组自合子变异的主要模式。通过比较宗教群体和非宗教群体之间的自合性，研究了荷兰人群的群体内变异。荷兰有一个基于宗教信仰的社会隔离和分类的历史，这可能增加了宗教团体内父母的关系。宗教与几种精神表型有关，如重度抑郁症（MDD）。我们调查了自合子和重度抑郁症之间是否存在关联，以及这种关联在多大程度上可以用宗教信仰来解释。所有Froh分析都包括对祖先信息主成分（PCs）和地理因素的调整。宗教信仰与自合子显著相关，这表明Froh有能力捕捉到种群内的差异，而这些差异不是由祖先信息pc或地理因素捕捉到的。非宗教群体的Froh值明显较低，MDD病例明显较多，导致自合子与抑郁症之间名义上显着负相关。在考虑宗教信仰后，MDD与Froh不相关，表明MDD与近交的关系是分层的。这项研究表明，在一个相对较小的国家，过去的宗教分类和最近的世俗化如何产生遗传后果。这保证了历史社会背景及其对精神病学和其他相关特征的关联研究中遗传变异的影响。
The effects of inbreeding on the health of offspring can be studied by measuring genome-wide autozygosity as the proportion of the genome in runs of homozygosity (Froh) and relate Froh to outcomes such as psychiatric phenotypes. To successfully conduct these studies, the main patterns of variation for genome-wide autozygosity between and within populations should be well understood and accounted for. Within population variation was investigated in the Dutch population by comparing autozygosity between religious and non-religious groups. The Netherlands have a history of societal segregation and assortment based on religious affiliation, which may have increased parental relatedness within religious groups. Religion has been associated with several psychiatric phenotypes, such as major depressive disorder (MDD). We investigated whether there is an association between autozygosity and MDD, and the extent to which this association can be explained by religious affiliation. All Froh analyses included adjustment for ancestry-informative principal components (PCs) and geographic factors. Religious affiliation was significantly associated with autozygosity, showing that Froh has the ability to capture within population differences that are not captured by ancestry-informative PCs or geographic factors. The non-religious group had significantly lower Froh values and significantly more MDD cases, leading to a nominally significant negative association between autozygosity and depression. After accounting for religious affiliation, MDD was not associated with Froh, indicating that the relation between MDD and inbreeding was due to stratification. This study shows how past religious assortment and recent secularization can have genetic consequences in a relatively small country. This warrants accounting for the historical social context and its effects on genetic variation in association studies on psychiatric and other related traits.
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DOI：
10.1192/pb.bp.109.025924
发表时间：
2010-02-01
期刊：
PSYCHIATRIC BULLETIN
影响因子：
--
作者：
Dein, Simon;Cook, Christopher C. H.;Eagger, Sarah
通讯作者：
Eagger, Sarah
影响因子：
4.5
作者：
Haber, Marc;Gauguier, Dominique;Zalloua, Pierre A.
通讯作者：
Zalloua, Pierre A.
影响因子：
6.9
作者：
Marcelis, M;Navarro-Mateu, F;van Os, J
通讯作者：
van Os, J
影响因子：
4.5
作者：
Keller MC;Simonson MA;Ripke S;Neale BM;Gejman PV;Howrigan DP;Lee SH;Lencz T;Levinson DF;Sullivan PF;Schizophrenia Psychiatric Genome-Wide Association Study Consortium
通讯作者：
Schizophrenia Psychiatric Genome-Wide Association Study Consortium
影响因子：
3.3
作者：
DeRose, MA;Roff, DA
通讯作者：
Roff, DA