Endogenous estradiol contributes to vascular endothelial dysfunction in premenopausal women with type 1 diabetes.
Endogenous estradiol contributes to vascular endothelial dysfunction in premenopausal women with type 1 diabetes.
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DOI：
10.1186/s12933-023-01966-6
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发表时间：
2023-09-07
影响因子：
9.3
通讯作者：
Harris, Ryan A.
中科院分区：
文献类型：
--
作者：
Simon, Abigayle B.;Derella, Cassandra C.;Blackburn, Marsha;Thomas, Jeffrey;Layman, Lawrence C.;Nicholson, Matthew S.;Waller, Jennifer;Elmarakby, Ahmed;Saad, Karim M.;Harris, Ryan A.
内源性雌激素对健康绝经前妇女的心脏有保护作用。尽管雌激素具有这种有利的作用，但动物模型显示了雌二醇对糖尿病患者血管功能的不利影响。本研究旨在确定内源性雌二醇对女性1型糖尿病患者内皮功能的作用。32名1型糖尿病女性（HbA 1c = 8.6 ± 1.7%）和25名表面健康女性（HbA 1c = 5.2 ± 0.3%）参与了研究。血流介导的扩张（FMD），一氧化氮生物利用度和内皮功能的生物测定在月经（M）和月经周期的晚期卵泡（LF）阶段进行，分别代表低和高浓度的雌激素。此外，在每次访视时采集静脉血样，以分别测定雌二醇、硫代巴比妥酸反应物质（TBARS）和硝酸盐/亚硝酸盐（NOx）（氧化应激和一氧化氮的生物标志物）的循环浓度。收集了（1）在安慰剂周和第二个活性药物周期间使用口服激素避孕药（HBC）（HbA 1c = 8.3 ± 2.1%）的9名1型糖尿病女性的数据，以及（2）9名人口统计学匹配的未使用HBC（HbA 1c = 8.9 ± 2.1%）的1型糖尿病女性的亚组数据。总体而言，与M相比，1型糖尿病（Δ雌二醇= 75 ± 86 pg/mL）和对照组（Δ雌二醇= 71 ± 76 pg/mL）的LF期雌二醇显著增加;然而，与对照组（Δ TBARS = 0 ± 4 µM）相比，仅在1型糖尿病患者（Δ TBARS = 3 ± 13 µM）中观察到TBARS增加。M时两组的FMD相似（p = 0.406）。此外，FMD在对照组中从M期到LF期显著增加（p = 0.024），而在1型糖尿病中观察到减少。与未使用HBC的患者相比，使用HBC的患者FMD更大（p = 0.015），与月经周期阶段无关。内源性雌二醇增加氧化应激，导致糖尿病女性内皮功能障碍。此外，HBC的使用似乎有利于1型糖尿病的内皮功能。
Endogenous estrogen is cardio-protective in healthy premenopausal women. Despite this favorable action of estrogen, animal models depict a detrimental effect of estradiol on vascular function in the presence of diabetes. The present study sought to determine the role of endogenous estradiol on endothelial function in women with type 1 diabetes. 32 women with type 1 diabetes (HbA1c = 8.6 ± 1.7%) and 25 apparently healthy women (HbA1c = 5.2 ± 0.3%) participated. Flow-mediated dilation (FMD), a bioassay of nitric-oxide bioavailability and endothelial function was performed during menses (M) and the late follicular (LF) phase of the menstrual cycle to represent low and high concentrations of estrogen, respectively. In addition, a venous blood sample was collected at each visit to determine circulating concentrations of estradiol, thiobarbituric acid reactive substances (TBARS), and nitrate/nitrite (NOx), biomarkers of oxidative stress and nitric oxide, respectively. Data were collected in (1) 9 additional women with type 1 diabetes using oral hormonal birth control (HBC) (HbA1c = 8.3 ± 2.1%) during the placebo pill week and second active pill week, and (2) a subgroup of 9 demographically matched women with type 1 diabetes not using HBC (HbA1c = 8.9 ± 2.1%). Overall, estradiol was significantly increased during the LF phase compared to M in both type 1 diabetes (Δestradiol = 75 ± 86 pg/mL) and controls (Δestradiol = 71 ± 76 pg/mL); however, an increase in TBARS was only observed in patients with type 1 diabetes (ΔTBARS = 3 ± 13 µM) compared to controls (ΔTBARS = 0 ± 4 µM). FMD was similar (p = 0.406) between groups at M. In addition, FMD increased significantly from M to the LF phase in controls (p = 0.024), whereas a decrease was observed in type 1 diabetes. FMD was greater (p = 0.015) in patients using HBC compared to those not on HBC, independent of menstrual cycle phase. Endogenous estradiol increases oxidative stress and contributes to endothelial dysfunction in women with diabetes. Additionally, HBC use appears to be beneficial to endothelial function in type 1 diabetes.
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影响因子：
7.9
作者：
Iorga A;Cunningham CM;Moazeni S;Ruffenach G;Umar S;Eghbali M
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