Stimulation-Produced Analgesia
Stimulation-Produced Analgesia
复制标题
刺激镇痛
DOI：
10.1007/978-1-4614-7562-0_6
复制
发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
J. Liebeskind
中科院分区：
文献类型：
--
作者：
T. Wolfle;J. Liebeskind
虽然刺激产生的镇痛（SPA）不太可能很快成为兽医学的临床工具，但动物在提供有关对人类和动物最终有益的内源性疼痛控制系统的信息的研究中仍然是有价值的。科学上的许多里程碑都是以矛盾的方式完成的，就像慢性疼痛一样，许多进展都来自急性疼痛的行为模型。幸运的是，SPA在人类和动物之间有所不同。虽然在人类中，内侧脑干刺激减轻病理性疼痛而不影响正常（急性）疼痛感知，但后者通常用于定义动物中的SPA。此外，SPA在人类中的有效性持续时间大大超过动物。这些是真正的物种差异还是刺激或疼痛测量技术差异的结果尚不清楚。虽然动物不能用语言表达它们的痛苦，但它们的行为与人类对有害刺激的反应相似。这些行为中最基本的是逃避反应，它使身体或肢体免受组织破坏的威胁。SPA的一个常见的例子是，热板上的老鼠或热灯下的老鼠无法做出基本的逃避反应。
Although it is unlikely that stimulation-produced analgesia (SPA) will soon become a clinical tool in veterinary medicine, animals continue to be valuable in studies that provide information about an endogenous pain-control system of ultimate benefit to humans and to animals. Many milestones in science are accomplished paradoxically as with chronic pain where many advances have come from behavioral models of acute pain. Fortuitously, SPA differs somewhat between humans and animals. Although in humans medial brain stem stimulation alleviates pathological pain without affecting normal (acute) pain perception, the latter is typically used to define SPA in animals. Also the duration of SPA effectiveness in humans greatly exceeds that in animals. Whether these are true species differences or result from differences in techniques of stimulation or pain measurement is not yet known. Although animals can not verbally communicate their pain, their behavior is similar to that of humans in response to noxious stimulation. The most basic of these behaviors is the escape response, which removes the body or limb from threat of tissue destruction. A common demonstration of SPA is that a mouse on a hot plate or a rat with its tail under a heat lamp fails to make the basic escape response.
影响因子：
4.1
作者：
Wise Young;Eugene S. Flamm;H. Demopoulos;J. Tomasula;V. Decrescito
通讯作者：
Wise Young;Eugene S. Flamm;H. Demopoulos;J. Tomasula;V. Decrescito