Estimated rate of reactivation of latent tuberculosis infection in the United States, overall and by population subgroup.
Estimated rate of reactivation of latent tuberculosis infection in the United States, overall and by population subgroup.
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DOI：
10.1093/aje/kwt246
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发表时间：
2014-01-15
影响因子：
5
通讯作者：
Horsburgh CR Jr
中科院分区：
文献类型：
--
作者：
Shea KM;Kammerer JS;Winston CA;Navin TR;Horsburgh CR Jr
我们利用 2006 年至 2008 年期间向疾病控制与预防中心报告的结核病病例数据和结核分枝杆菌分离株基因分型数据，估计了美国结核病 (TB) 的总体复发率和按人群亚组的复发率。结核病再激活率定义为非基因型聚集性结核病病例数除以因流行潜伏性结核感染（LTBI）而面临再激活风险的人年数。 LTBI 是通过 1999-2000 年国家健康和营养检查调查期间进行的结核菌素皮肤测试确定的。结核病病例的聚类是使用疾病控制和预防中心收集的结核病基因分型数据确定的，并通过空间扫描统计进行分析。在 2006 年至 2008 年期间报告的 39,920 例结核病病例中，79.7% 归因于重新激活。 LTBI 患者中结核病再激活的总体比率估计为每 100 人年 0.084 例（95% 置信区间 (CI)：0.083, 0.085）例。患有和未患有人类免疫缺陷病毒合并感染者的比率分别为每 100 人年 1.82 (95% CI: 1.74, 1.89) 和 0.073 (95% CI: 0.070, 0.075) 例。国外出生的 LTBI 患者的结核病再激活率（0.098 例/100 人年；95% CI：0.096，0.10）高于美国出生的患者（0.082 例/100 人年；95% CI：0.080，0.083）。各亚组结核病再激活率的差异支持了当前针对 LTBI 针对性检测和治疗的建议。
We estimated the rate of reactivation tuberculosis (TB) in the United States, overall and by population subgroup, using data on TB cases and Mycobacterium tuberculosis isolate genotyping reported to the Centers for Disease Control and Prevention during 2006–2008. The rate of reactivation TB was defined as the number of non-genotypically clustered TB cases divided by the number of person-years at risk for reactivation due to prevalent latent TB infection (LTBI). LTBI was ascertained from tuberculin skin tests given during the 1999–2000 National Health and Nutrition Examination Survey. Clustering of TB cases was determined using TB genotyping data collected by the Centers for Disease Control and Prevention and analyzed via spatial scan statistic. Of the 39,920 TB cases reported during 2006–2008, 79.7% were attributed to reactivation. The overall rate of reactivation TB among persons with LTBI was estimated as 0.084 (95% confidence interval (CI): 0.083, 0.085) cases per 100 person-years. Rates among persons with and without human immunodeficiency virus coinfection were 1.82 (95% CI: 1.74, 1.89) and 0.073 (95% CI: 0.070, 0.075) cases per 100 person-years, respectively. The rate of reactivation TB among persons with LTBI was higher among foreign-born persons (0.098 cases/100 person-years; 95% CI: 0.096, 0.10) than among persons born in the United States (0.082 cases/100 person-years; 95% CI: 0.080, 0.083). Differences in rates of TB reactivation across subgroups support current recommendations for targeted testing and treatment of LTBI.
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使用基因分型和地理空间扫描来估计美国最近的结核分枝杆菌传播。
影响因子：
11.8
作者：
Moonan PK;Ghosh S;Oeltmann JE;Kammerer JS;Cowan LS;Navin TR
通讯作者：
Navin TR
影响因子：
0.8
作者：
Kulldorff, M
通讯作者：
Kulldorff, M
影响因子：
3.7
作者：
Ricks, Philip M.;Cain, Kevin P.;Moonan, Patrick K.
通讯作者：
Moonan, Patrick K.
影响因子：
11.8
作者：
Lee, E;Holzman, RS
通讯作者：
Holzman, RS
DOI：
10.5588/ijtld.11.0015
发表时间：
2011-11-01
影响因子：
4
作者：
Larson, E. M.;O'Donnell, M.;von Reyn, C. Fordham
通讯作者：
von Reyn, C. Fordham